Dexamethasone and Rifampin Interaction
Drug interaction information between Dexamethasone and Rifampin.
Dexamethasone and Rifampin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dexamethasone and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin speeds up the liver's ability to break down dexamethasone. This causes the steroid to leave your body faster and makes it less effective.
FDA Label Information
Hepatic Enzyme Inducers, Inhibitors and Substrates: Drugs which induce cytochrome P450 3A4 (CYP 3A4) enzyme activity (e.g., barbiturates, phenytoin, carbamazepine, rifampin) may enhance the metabolism of corticosteroids and require that the dosage of the corticosteroid be increased.
Dexamethasone Also Interacts With
- Aspirin moderate
- Ketoconazole moderate
- Nirmatrelvir/Ritonavir moderate
- Warfarin minor
- Cyclosporine minor
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Dexamethasone + Rifampin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Dexamethasone's 21. In the minor band specifically: Dexamethasone has 18 (also Warfarin, Cyclosporine, Hydrocortisone, Erythromycin); Rifampin has 103 (also Metoprolol, Losartan, Simvastatin, Glipizide).
What mechanism field is on file for Dexamethasone and Rifampin?
Rifampin speeds up the liver's ability to break down dexamethasone. This causes the steroid to leave your body faster and makes it less effective.
Rifampin carries more major-labeled pairs than Dexamethasone
SPL source-record counts only. This page's band is minor · classes on file: Dexamethasone (Corticosteroid); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Dexamethasone's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 18 minor · 21 total
- Other minor peers for Dexamethasone
- Warfarin
- Cyclosporine
- Hydrocortisone
- Erythromycin
8 major · 26 moderate · 103 minor · 137 total
- Other minor peers for Rifampin
- Metoprolol
- Losartan
- Simvastatin
- Glipizide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.