What the FDA labels say about taking them together
Aspirin and dexamethasone
Dexamethasone's FDA label of June 6, 2025 names aspirin in its drug interactions section; the aspirin label PlainMeds reads does not name dexamethasone. The dexamethasone label: “Nonsteroidal Anti-Inflammatory Agents (NSAIDS) Concomitant use of aspirin and corticosteroids increases the risk of gastrointestinal side effects.”
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the dexamethasone FDA label on DailyMed (effective June 6, 2025, Hikma Pharmaceuticals USA, Inc.).
What does the aspirin label say about dexamethasone?
Aspirin's label (effective September 9, 2025) does not name dexamethasone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the dexamethasone label say about aspirin?
Dexamethasone label, drug interactionsNonsteroidal Anti-Inflammatory Agents (NSAIDS): Concomitant use of aspirin (or other nonsteroidal anti-inflammatory agents) and corticosteroids increases the risk of gastrointestinal side effects.
Source: FDA drug label (Hemady, NDA211379), Edenbridge Pharmaceuticals LLC., effective January 9, 2026 (SPL set 6b9cf32c-6d60-4853-bbfd-2304ffc2c129), via openFDA
Source: FDA drug label (Dexamethasone Intensol), Hikma Pharmaceuticals USA, Inc., effective June 6, 2025 (SPL set b15200fb-1826-472b-a907-e677a272513b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Dexamethasone | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | Asthma, Eczema (atopic dermatitis), Leukemia, lymphoma and myeloma, Herpes and shingles, Crohn's disease and ulcerative colitis, Multiple sclerosis, Osteoarthritis, Rheumatoid arthritis, Psoriasis, Allergies, Anemia, Pain |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | $0.193 per tablet 4 mg tablet |
| Shortage now | A presentation being discontinued | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once