Dexamethasone and Aspirin Interaction
Drug interaction information between Dexamethasone and Aspirin.
Dexamethasone and Aspirin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Dexamethasone and Aspirin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these drugs can irritate the lining of your stomach and digestive tract. Taking them together makes it more likely that you will develop stomach pain, ulcers, or bleeding.
FDA Label Information
Nonsteroidal Anti-Inflammatory Agents (NSAIDS): Concomitant use of aspirin (or other nonsteroidal ant i nflammatory agents) and corticosteroids increases the risk of gastrointestinal side effects. Aspirin should be used cautiously in conjunction with corticosteroids in hypoprothrombinemia.
Dexamethasone Also Interacts With
- Ketoconazole moderate
- Nirmatrelvir/Ritonavir moderate
- Warfarin minor
- Cyclosporine minor
- Hydrocortisone minor
Aspirin Also Interacts With
- Atenolol major
- Fluoxetine major
- Ibandronate major
- Alendronate moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Dexamethasone + Aspirin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aspirin has 47 labeled pairs on file vs Dexamethasone's 21. In the moderate band specifically: Dexamethasone has 3 (also Ketoconazole, Nirmatrelvir/Ritonavir); Aspirin has 12 (also Alendronate, Apixaban, Desvenlafaxine, Duloxetine).
What mechanism field is on file for Dexamethasone and Aspirin?
Both of these drugs can irritate the lining of your stomach and digestive tract. Taking them together makes it more likely that you will develop stomach pain, ulcers, or bleeding.
Aspirin carries more major-labeled pairs than Dexamethasone
SPL source-record counts only. This page's band is moderate · classes on file: Dexamethasone (Corticosteroid); Aspirin (Antiplatelet / NSAID).
Aspirin has 3 major-labeled pairs vs Dexamethasone's 0. This page itself is in the moderate band, not the major band.
0 major · 3 moderate · 18 minor · 21 total
- Other moderate peers for Dexamethasone
- Ketoconazole
- Nirmatrelvir/Ritonavir
3 major · 12 moderate · 32 minor · 47 total
- Other moderate peers for Aspirin
- Alendronate
- Apixaban
- Desvenlafaxine
- Duloxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.