What the FDA labels say about taking them together
Bupropion and deutetrabenazine
Deutetrabenazine's FDA label of February 28, 2025 names bupropion in its drug interactions section; the bupropion labels PlainMeds reads (4) do not name deutetrabenazine. The deutetrabenazine label: “Concomitant use of strong CYP2D6 inhibitors has been shown to increase the systemic exposure to the active dihydro-metabolites of deutetrabenazine by approximately 3-fold.”
Check it at the source: the bupropion FDA label on DailyMed (effective June 21, 2024); the deutetrabenazine FDA label on DailyMed (effective February 28, 2025, Teva Neuroscience, Inc.).
What does the bupropion label say about deutetrabenazine?
Bupropion's label (effective June 21, 2024) and its 3 other brand-application labels do not name deutetrabenazine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (BUPROPION HYDROCHLORIDE), Epic Pharma LLC, effective June 21, 2024 (SPL set 9fb44e96-6160-4a4a-90cb-91764c0dcd89), via openFDA; the full label on DailyMed
What does the deutetrabenazine label say about bupropion?
Deutetrabenazine label, drug interactionsConcomitant use of strong CYP2D6 inhibitors (e.g., paroxetine, fluoxetine, quinidine, bupropion) has been shown to increase the systemic exposure to the active dihydro-metabolites of deutetrabenazine by approximately 3-fold.
Source: FDA drug label (Austedo), Teva Neuroscience, Inc., effective February 28, 2025 (SPL set 7ea3c60a-45c7-44cc-afc2-d87fa53993c0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bupropion | Deutetrabenazine | |
|---|---|---|
| Labeled for | Depression, Quitting smoking | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0785 per tablet 150 mg tablet | $249.32 per unit 12-18-24-30 mg) |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once