Deutetrabenazine and Bupropion Interaction
Drug interaction information between Deutetrabenazine and Bupropion.
Deutetrabenazine and Bupropion have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Deutetrabenazine and Bupropion. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Bupropion slows down the liver enzyme that clears deutetrabenazine from your body, causing the drug to build up.
FDA Label Information
Concomitant use of strong CYP2D6 inhibitors (e.g., paroxetine, fluoxetine, quinidine, bupropion) has been shown to increase the systemic exposure to the active dihydro-metabolites of deutetrabenazine by approximately 3-fold.
Deutetrabenazine Also Interacts With
- Valbenazine major
- Tetrabenazine major
- Dopamine moderate
- Norepinephrine moderate
- Fluoxetine minor
Bupropion Also Interacts With
- Tranylcypromine major
- Theophylline moderate
- Isavuconazonium moderate
- Metoprolol minor
- Sertraline minor
Frequently Asked Questions
What SPL severity band is on file for Deutetrabenazine + Bupropion?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Bupropion has 35 labeled pairs on file vs Deutetrabenazine's 7. In the minor band specifically: Deutetrabenazine has 3 (also Fluoxetine, Paroxetine); Bupropion has 32 (also Metoprolol, Sertraline, Fluoxetine, Clopidogrel).
What mechanism field is on file for Deutetrabenazine and Bupropion?
Bupropion slows down the liver enzyme that clears deutetrabenazine from your body, causing the drug to build up.
Deutetrabenazine carries more major-labeled pairs than Bupropion
SPL source-record counts only. This page's band is minor · classes on file: Deutetrabenazine (VMAT2 Inhibitor); Bupropion (Norepinephrine-Dopamine Reuptake Inhibitor (NDRI)).
Deutetrabenazine has 2 major-labeled pairs vs Bupropion's 1. This page itself is in the minor band, not the major band.
2 major · 2 moderate · 3 minor · 7 total
- Other minor peers for Deutetrabenazine
- Fluoxetine
- Paroxetine
1 major · 2 moderate · 32 minor · 35 total
- Other minor peers for Bupropion
- Metoprolol
- Sertraline
- Fluoxetine
- Clopidogrel
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.