Deutetrabenazine and Bupropion Interaction
Drug interaction information between Deutetrabenazine and Bupropion.
Deutetrabenazine and Bupropion have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Deutetrabenazine and Bupropion. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Bupropion slows down the liver enzyme that clears deutetrabenazine from your body, causing the drug to build up.
What To Do
Your doctor may need to reduce your dose of deutetrabenazine to prevent it from reaching unsafe levels.
FDA Label Information
Concomitant use of strong CYP2D6 inhibitors (e.g., paroxetine, fluoxetine, quinidine, bupropion) has been shown to increase the systemic exposure to the active dihydro-metabolites of deutetrabenazine by approximately 3-fold.
Deutetrabenazine Also Interacts With
- Valbenazine major
- Tetrabenazine major
- Dopamine moderate
- Norepinephrine moderate
- Fluoxetine minor
Bupropion Also Interacts With
- Tranylcypromine major
- Theophylline moderate
- Isavuconazonium moderate
- Metoprolol minor
- Sertraline minor
Frequently Asked Questions
Can I take Deutetrabenazine and Bupropion together?
This is a minor interaction. Your doctor may need to reduce your dose of deutetrabenazine to prevent it from reaching unsafe levels.
How serious is the interaction between Deutetrabenazine and Bupropion?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Deutetrabenazine and Bupropion interact?
Bupropion slows down the liver enzyme that clears deutetrabenazine from your body, causing the drug to build up.
Understanding the Deutetrabenazine and Bupropion Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Deutetrabenazine belongs to the VMAT2 Inhibitor class and Bupropion belongs to the Norepinephrine-Dopamine Reuptake Inhibitor (NDRI) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Bupropion slows down the liver enzyme that clears deutetrabenazine from your body, causing the drug to build up. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Deutetrabenazine has 7 total documented interactions on file in this dataset, and Bupropion has 35. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor may need to reduce your dose of deutetrabenazine to prevent it from reaching unsafe levels. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Deutetrabenazine or Bupropion based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.