What the FDA labels say about taking them together
Deutetrabenazine and fluoxetine
Deutetrabenazine's FDA label of February 28, 2025 names fluoxetine in its drug interactions section; the fluoxetine label PlainMeds reads does not name deutetrabenazine. The deutetrabenazine label: “Concomitant use of strong CYP2D6 inhibitors has been shown to increase the systemic exposure to the active dihydro-metabolites of deutetrabenazine by approximately 3-fold.”
Check it at the source: the deutetrabenazine FDA label on DailyMed (effective February 28, 2025, Teva Neuroscience, Inc.); the fluoxetine FDA label on DailyMed (effective January 8, 2026, Dista Products Company).
What does the deutetrabenazine label say about fluoxetine?
Deutetrabenazine label, drug interactionsConcomitant use of strong CYP2D6 inhibitors (e.g., paroxetine, fluoxetine, quinidine, bupropion) has been shown to increase the systemic exposure to the active dihydro-metabolites of deutetrabenazine by approximately 3-fold.
Source: FDA drug label (Austedo), Teva Neuroscience, Inc., effective February 28, 2025 (SPL set 7ea3c60a-45c7-44cc-afc2-d87fa53993c0), via openFDA; the full label on DailyMed
What does the fluoxetine label say about deutetrabenazine?
Fluoxetine's label (effective January 8, 2026) does not name deutetrabenazine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Prozac), NDA018936 (Eli Lilly And Co), as published by Dista Products Company, effective January 8, 2026 (SPL set c88f33ed-6dfb-4c5e-bc01-d8e36dd97299), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Deutetrabenazine | Fluoxetine | |
|---|---|---|
| Labeled for | n/a | Depression, Anxiety, Bipolar disorder |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $249.32 per unit 12-18-24-30 mg) | $0.0519 per capsule 40 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once