Deutetrabenazine and Fluoxetine Interaction
Drug interaction information between Deutetrabenazine and Fluoxetine.
Deutetrabenazine and Fluoxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Deutetrabenazine and Fluoxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluoxetine blocks the liver's ability to break down deutetrabenazine, which can triple the amount of the drug in your blood.
FDA Label Information
Concomitant use of strong CYP2D6 inhibitors (e.g., paroxetine, fluoxetine, quinidine, bupropion) has been shown to increase the systemic exposure to the active dihydro-metabolites of deutetrabenazine by approximately 3-fold.
Deutetrabenazine Also Interacts With
- Valbenazine major
- Tetrabenazine major
- Dopamine moderate
- Norepinephrine moderate
- Bupropion minor
Fluoxetine Also Interacts With
- Aspirin major
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
Frequently Asked Questions
What SPL severity band is on file for Deutetrabenazine + Fluoxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluoxetine has 68 labeled pairs on file vs Deutetrabenazine's 7. In the minor band specifically: Deutetrabenazine has 3 (also Bupropion, Paroxetine); Fluoxetine has 43 (also Ketoconazole, Lithium, Moxifloxacin, Erythromycin).
What mechanism field is on file for Deutetrabenazine and Fluoxetine?
Fluoxetine blocks the liver's ability to break down deutetrabenazine, which can triple the amount of the drug in your blood.
Fluoxetine carries more major-labeled pairs than Deutetrabenazine
SPL source-record counts only. This page's band is minor · classes on file: Deutetrabenazine (VMAT2 Inhibitor); Fluoxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Fluoxetine has 6 major-labeled pairs vs Deutetrabenazine's 2. This page itself is in the minor band, not the major band.
2 major · 2 moderate · 3 minor · 7 total
- Other minor peers for Deutetrabenazine
- Bupropion
- Paroxetine
6 major · 19 moderate · 43 minor · 68 total
- Other minor peers for Fluoxetine
- Ketoconazole
- Lithium
- Moxifloxacin
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.