Deutetrabenazine and Dopamine Interaction
Drug interaction information between Deutetrabenazine and Dopamine.
Deutetrabenazine and Dopamine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Deutetrabenazine and Dopamine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This drug lowers the amount of dopamine available in the brain. Taking it with other drugs that affect dopamine can increase the risk of serious movement-related side effects like stiffness or restlessness.
FDA Label Information
7.4 Neuroleptic Drugs The risk of parkinsonism, NMS, and akathisia may be increased by concomitant use of AUSTEDO XR or AUSTEDO with dopamine antagonists or antipsychotics.
Deutetrabenazine Also Interacts With
- Valbenazine major
- Tetrabenazine major
- Norepinephrine moderate
- Bupropion minor
- Fluoxetine minor
Dopamine Also Interacts With
- Carbidopa/Levodopa moderate
- Digoxin moderate
- Tetrabenazine moderate
- Tranylcypromine moderate
- Amitriptyline minor
Frequently Asked Questions
What SPL severity band is on file for Deutetrabenazine + Dopamine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Dopamine has 28 labeled pairs on file vs Deutetrabenazine's 7. In the moderate band specifically: Deutetrabenazine has 2 (also Norepinephrine); Dopamine has 5 (also Carbidopa/Levodopa, Digoxin, Tetrabenazine, Tranylcypromine).
What mechanism field is on file for Deutetrabenazine and Dopamine?
This drug lowers the amount of dopamine available in the brain. Taking it with other drugs that affect dopamine can increase the risk of serious movement-related side effects like stiffness or restlessness.
Deutetrabenazine carries more major-labeled pairs than Dopamine
SPL source-record counts only. This page's band is moderate · classes on file: Deutetrabenazine (VMAT2 Inhibitor); Dopamine (Inotropic / Vasopressor).
Deutetrabenazine has 2 major-labeled pairs vs Dopamine's 0. This page itself is in the moderate band, not the major band.
2 major · 2 moderate · 3 minor · 7 total
- Other moderate peers for Deutetrabenazine
- Norepinephrine
0 major · 5 moderate · 23 minor · 28 total
- Other moderate peers for Dopamine
- Carbidopa/Levodopa
- Digoxin
- Tetrabenazine
- Tranylcypromine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.