Deutetrabenazine and Valbenazine Interaction
Drug interaction information between Deutetrabenazine and Valbenazine.
Deutetrabenazine and Valbenazine have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Deutetrabenazine and Valbenazine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two medicines work in the same way, and taking them at the same time can cause the drug effects to become too strong and unsafe.
FDA Label Information
7.6 Concomitant Tetrabenazine or Valbenazine AUSTEDO XR and AUSTEDO are contraindicated in patients currently taking tetrabenazine or valbenazine.
Deutetrabenazine Also Interacts With
- Tetrabenazine major
- Dopamine moderate
- Norepinephrine moderate
- Bupropion minor
- Fluoxetine minor
Valbenazine Also Interacts With
- Tetrabenazine major
- Digoxin moderate
- Itraconazole minor
Frequently Asked Questions
What SPL severity band is on file for Deutetrabenazine + Valbenazine?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Deutetrabenazine has 7 labeled pairs on file vs Valbenazine's 4. In the major band specifically: Deutetrabenazine has 2 (also Tetrabenazine); Valbenazine has 2 (also Tetrabenazine).
What mechanism field is on file for Deutetrabenazine and Valbenazine?
These two medicines work in the same way, and taking them at the same time can cause the drug effects to become too strong and unsafe.
Deutetrabenazine's labeled portfolio outnumbers Valbenazine
SPL source-record counts only. This page's band is major · classes on file: Deutetrabenazine (VMAT2 Inhibitor); Valbenazine (VMAT2 Inhibitor).
2 major · 2 moderate · 3 minor · 7 total
- Other major peers for Deutetrabenazine
- Tetrabenazine
2 major · 1 moderate · 1 minor · 4 total
- Other major peers for Valbenazine
- Tetrabenazine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.