Deutetrabenazine and Tetrabenazine Interaction
Drug interaction information between Deutetrabenazine and Tetrabenazine.
Deutetrabenazine and Tetrabenazine have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Deutetrabenazine and Tetrabenazine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two drugs are very similar and work in the same way to treat movement disorders. Taking them together can lead to an overdose of the same medicine type and cause severe side effects.
FDA Label Information
7.7 Concomitant Deutetrabenazine or Valbenazine Tetrabenazine is contraindicated in patients currently taking deutetrabenazine or valbenazine.
Deutetrabenazine Also Interacts With
- Valbenazine major
- Dopamine moderate
- Norepinephrine moderate
- Bupropion minor
- Fluoxetine minor
Tetrabenazine Also Interacts With
- Valbenazine major
- Olanzapine moderate
- Risperidone moderate
- Ziprasidone moderate
- Haloperidol moderate
Frequently Asked Questions
What SPL severity band is on file for Deutetrabenazine + Tetrabenazine?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tetrabenazine has 16 labeled pairs on file vs Deutetrabenazine's 7. In the major band specifically: Deutetrabenazine has 2 (also Valbenazine); Tetrabenazine has 2 (also Valbenazine).
What mechanism field is on file for Deutetrabenazine and Tetrabenazine?
These two drugs are very similar and work in the same way to treat movement disorders. Taking them together can lead to an overdose of the same medicine type and cause severe side effects.
Tetrabenazine's labeled portfolio outnumbers Deutetrabenazine
SPL source-record counts only. This page's band is major · classes on file: Deutetrabenazine (VMAT2 Inhibitor); Tetrabenazine (VMAT2 Inhibitor).
2 major · 2 moderate · 3 minor · 7 total
- Other major peers for Deutetrabenazine
- Valbenazine
2 major · 9 moderate · 5 minor · 16 total
- Other major peers for Tetrabenazine
- Valbenazine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.