Deutetrabenazine and Norepinephrine Interaction
Drug interaction information between Deutetrabenazine and Norepinephrine.
Deutetrabenazine and Norepinephrine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Deutetrabenazine and Norepinephrine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
This medication can lower the levels of norepinephrine in your brain. Taking it when levels are already low could cause a severe and dangerous drop in this important chemical.
What To Do
Your doctor will wait for your symptoms to return before starting this medication to ensure your chemical levels are safe.
FDA Label Information
Prescribers should wait for chorea or dyskinesia to reemerge before administering AUSTEDO XR or AUSTEDO to help reduce the risk of overdosage and major depletion of serotonin and norepinephrine in the central nervous system.
Deutetrabenazine Also Interacts With
- Valbenazine major
- Tetrabenazine major
- Dopamine moderate
- Bupropion minor
- Fluoxetine minor
Norepinephrine Also Interacts With
- Tranylcypromine major
- Carbidopa/Levodopa moderate
- Clopidogrel moderate
- Digoxin moderate
- Edoxaban moderate
Frequently Asked Questions
Can I take Deutetrabenazine and Norepinephrine together?
This is a moderate interaction. Your doctor will wait for your symptoms to return before starting this medication to ensure your chemical levels are safe.
How serious is the interaction between Deutetrabenazine and Norepinephrine?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Deutetrabenazine and Norepinephrine interact?
This medication can lower the levels of norepinephrine in your brain. Taking it when levels are already low could cause a severe and dangerous drop in this important chemical.
Understanding the Deutetrabenazine and Norepinephrine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Deutetrabenazine belongs to the VMAT2 Inhibitor class and Norepinephrine belongs to the Vasopressor (Alpha-1 Agonist) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: This medication can lower the levels of norepinephrine in your brain. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Deutetrabenazine has 7 total documented interactions on file in this dataset, and Norepinephrine has 50. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor will wait for your symptoms to return before starting this medication to ensure your chemical levels are safe. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Deutetrabenazine or Norepinephrine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.