Carvedilol and Fluoxetine Interaction
Drug interaction information between Carvedilol and Fluoxetine.
Carvedilol and Fluoxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Carvedilol and Fluoxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluoxetine blocks the enzyme that normally clears carvedilol from your blood. This can lead to higher levels of carvedilol in your body.
FDA Label Information
( 7.8 ) 7.1 CYP2D6 Inhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol [see Clinical Pharmacology ( 12.3 )] .
Carvedilol Also Interacts With
- Clonidine moderate
- Paroxetine minor
- Diltiazem minor
- Fluconazole minor
- Verapamil minor
Fluoxetine Also Interacts With
- Aspirin major
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
Frequently Asked Questions
What SPL severity band is on file for Carvedilol + Fluoxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluoxetine has 68 labeled pairs on file vs Carvedilol's 13. In the minor band specifically: Carvedilol has 12 (also Paroxetine, Diltiazem, Fluconazole, Verapamil); Fluoxetine has 43 (also Ketoconazole, Lithium, Moxifloxacin, Erythromycin).
What mechanism field is on file for Carvedilol and Fluoxetine?
Fluoxetine blocks the enzyme that normally clears carvedilol from your blood. This can lead to higher levels of carvedilol in your body.
Fluoxetine carries more major-labeled pairs than Carvedilol
SPL source-record counts only. This page's band is minor · classes on file: Carvedilol (Beta-Blocker (Alpha/Beta)); Fluoxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Fluoxetine has 6 major-labeled pairs vs Carvedilol's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 12 minor · 13 total
- Other minor peers for Carvedilol
- Paroxetine
- Diltiazem
- Fluconazole
- Verapamil
6 major · 19 moderate · 43 minor · 68 total
- Other minor peers for Fluoxetine
- Ketoconazole
- Lithium
- Moxifloxacin
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.