Carvedilol and Fluoxetine Interaction
Drug interaction information between Carvedilol and Fluoxetine.
Carvedilol and Fluoxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Carvedilol and Fluoxetine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Fluoxetine blocks the enzyme that normally clears carvedilol from your blood. This can lead to higher levels of carvedilol in your body.
What To Do
Your doctor should monitor your heart rate and blood pressure closely. They may need to adjust your carvedilol dose.
FDA Label Information
( 7.8 ) 7.1 CYP2D6 Inhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol [see Clinical Pharmacology ( 12.3 )] .
Carvedilol Also Interacts With
- Clonidine moderate
- Paroxetine minor
- Diltiazem minor
- Fluconazole minor
- Verapamil minor
Fluoxetine Also Interacts With
- Aspirin major
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
Frequently Asked Questions
Can I take Carvedilol and Fluoxetine together?
This is a minor interaction. Your doctor should monitor your heart rate and blood pressure closely. They may need to adjust your carvedilol dose.
How serious is the interaction between Carvedilol and Fluoxetine?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Carvedilol and Fluoxetine interact?
Fluoxetine blocks the enzyme that normally clears carvedilol from your blood. This can lead to higher levels of carvedilol in your body.
Understanding the Carvedilol and Fluoxetine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Carvedilol belongs to the Beta-Blocker (Alpha/Beta) class and Fluoxetine belongs to the Selective Serotonin Reuptake Inhibitor (SSRI) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Fluoxetine blocks the enzyme that normally clears carvedilol from your blood. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Carvedilol has 13 total documented interactions on file in this dataset, and Fluoxetine has 68. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should monitor your heart rate and blood pressure closely. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Carvedilol or Fluoxetine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.