What the FDA labels say about taking them together
Carvedilol and diltiazem
Carvedilol's FDA label of July 31, 2026 names diltiazem in its drug interactions section; diltiazem's label does not name carvedilol itself but warns about its class (Beta blockers). The carvedilol label: “As with other β-blockers, if COREG is administered with calcium channel blockers of the verapamil or diltiazem type, it is recommended that ECG and blood pressure be monitored.”
Check it at the source: the carvedilol FDA label on DailyMed (effective July 31, 2026, Waylis Therapeutics LLC); the diltiazem FDA label on DailyMed (effective August 7, 2026, Bausch Health US, LLC).
What does the carvedilol label say about diltiazem?
Carvedilol label, drug interactionsAs with other β-blockers, if COREG is administered with calcium channel blockers of the verapamil or diltiazem type, it is recommended that ECG and blood pressure be monitored.
Source: FDA drug label (Coreg Cr, NDA022012), Waylis Therapeutics LLC, effective April 25, 2025 (SPL set d3625d78-6eb6-41fe-8f6f-664965c104c4), via openFDA
Source: FDA drug label (Coreg), Waylis Therapeutics LLC, effective July 31, 2026 (SPL set 07c619c6-4a0c-445e-94fa-664a54f68a39), via openFDA; the full label on DailyMed
What does the diltiazem label say about carvedilol?
Diltiazem's label does not name carvedilol itself; it warns about its class (Beta blockers):
Diltiazem label, drug interactionsBeta-blockers, digitalis, and other agents known to impair cardiac contractility and conduction may increase risk for hypotension, bradycardia, and heart failure.
Diltiazem label, drug interactionsPharmacologic studies indicate that there may be additive effects in prolonging AV conduction when using beta-blockers or digitalis concomitantly with Tiazac (see WARNINGS ).
Source: FDA drug label (TIAZAC EXTENDED RELEASE), Bausch Health US, LLC, effective August 7, 2026 (SPL set c567fe7e-887e-4291-a0d1-2dd3f25cbf25), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Carvedilol | Diltiazem | |
|---|---|---|
| Labeled for | Heart failure, High blood pressure | High blood pressure, Angina, Atrial fibrillation |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0179 per tablet 6.25 mg tablet | $0.144 per capsule 24h ER(cd) 120 mg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once