What the FDA labels say about taking them together
Carvedilol and fluconazole
Carvedilol's FDA label of July 31, 2026 names fluconazole in its drug interactions section; the fluconazole labels PlainMeds reads (2) do not name carvedilol.
Check it at the source: the carvedilol FDA label on DailyMed (effective July 31, 2026, Waylis Therapeutics LLC); the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.).
What does the carvedilol label say about fluconazole?
Carvedilol label, drug interactionsThe concomitant administration of amiodarone or other CYP2C9 inhibitors such as fluconazole with COREG may enhance the β-blocking activity resulting in further slowing of the heart rate or cardiac conduction.
Source: FDA drug label (Coreg Cr, NDA022012), Waylis Therapeutics LLC, effective April 25, 2025 (SPL set d3625d78-6eb6-41fe-8f6f-664965c104c4), via openFDA
Source: FDA drug label (Coreg), Waylis Therapeutics LLC, effective July 31, 2026 (SPL set 07c619c6-4a0c-445e-94fa-664a54f68a39), via openFDA; the full label on DailyMed
What does the fluconazole label say about carvedilol?
Fluconazole's label (effective April 7, 2026) and its 1 other brand-application label do not name carvedilol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Carvedilol | Fluconazole | |
|---|---|---|
| Labeled for | Heart failure, High blood pressure | Fungal infections, Urinary tract infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0179 per tablet 6.25 mg tablet | $0.380 per tablet 200 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once