Carvedilol and Fluconazole Interaction
Drug interaction information between Carvedilol and Fluconazole.
Carvedilol and Fluconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Carvedilol and Fluconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluconazole prevents the body from breaking down carvedilol properly. This leads to higher levels of the drug in your system, which can slow your heart rate too much.
FDA Label Information
The concomitant administration of amiodarone or other CYP2C9 inhibitors such as fluconazole with carvedilol may enhance the β-blocking activity, resulting in further slowing of the heart rate or cardiac conduction.
Carvedilol Also Interacts With
- Clonidine moderate
- Fluoxetine minor
- Paroxetine minor
- Diltiazem minor
- Verapamil minor
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Carvedilol + Fluconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluconazole has 67 labeled pairs on file vs Carvedilol's 13. In the minor band specifically: Carvedilol has 12 (also Fluoxetine, Paroxetine, Diltiazem, Verapamil); Fluconazole has 57 (also Amlodipine, Losartan, Hydrochlorothiazide, Meloxicam).
What mechanism field is on file for Carvedilol and Fluconazole?
Fluconazole prevents the body from breaking down carvedilol properly. This leads to higher levels of the drug in your system, which can slow your heart rate too much.
Fluconazole carries more major-labeled pairs than Carvedilol
SPL source-record counts only. This page's band is minor · classes on file: Carvedilol (Beta-Blocker (Alpha/Beta)); Fluconazole (Azole Antifungal).
Fluconazole has 3 major-labeled pairs vs Carvedilol's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 12 minor · 13 total
- Other minor peers for Carvedilol
- Fluoxetine
- Paroxetine
- Diltiazem
- Verapamil
3 major · 7 moderate · 57 minor · 67 total
- Other minor peers for Fluconazole
- Amlodipine
- Losartan
- Hydrochlorothiazide
- Meloxicam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.