Carvedilol and Fluconazole Interaction
Drug interaction information between Carvedilol and Fluconazole.
Carvedilol and Fluconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Carvedilol and Fluconazole. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Fluconazole prevents the body from breaking down carvedilol properly. This leads to higher levels of the drug in your system, which can slow your heart rate too much.
What To Do
Your doctor may need to watch your heart rate and adjust your medication if it becomes too slow.
FDA Label Information
The concomitant administration of amiodarone or other CYP2C9 inhibitors such as fluconazole with carvedilol may enhance the β-blocking activity, resulting in further slowing of the heart rate or cardiac conduction.
Carvedilol Also Interacts With
- Clonidine moderate
- Fluoxetine minor
- Paroxetine minor
- Diltiazem minor
- Verapamil minor
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Frequently Asked Questions
Can I take Carvedilol and Fluconazole together?
This is a minor interaction. Your doctor may need to watch your heart rate and adjust your medication if it becomes too slow.
How serious is the interaction between Carvedilol and Fluconazole?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Carvedilol and Fluconazole interact?
Fluconazole prevents the body from breaking down carvedilol properly. This leads to higher levels of the drug in your system, which can slow your heart rate too much.
Understanding the Carvedilol and Fluconazole Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Carvedilol belongs to the Beta-Blocker (Alpha/Beta) class and Fluconazole belongs to the Azole Antifungal class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Fluconazole prevents the body from breaking down carvedilol properly. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Carvedilol has 13 total documented interactions on file in this dataset, and Fluconazole has 67. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor may need to watch your heart rate and adjust your medication if it becomes too slow. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Carvedilol or Fluconazole based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.