What the FDA labels say about taking them together
Carvedilol and paroxetine
Carvedilol's FDA label of July 31, 2026 names paroxetine in its drug interactions section; the paroxetine labels PlainMeds reads (4) do not name carvedilol. The carvedilol label: “Inhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of …”
Check it at the source: the carvedilol FDA label on DailyMed (effective July 31, 2026, Waylis Therapeutics LLC); the paroxetine FDA label on DailyMed (effective February 12, 2026, Mylan Pharmaceuticals Inc.).
What does the carvedilol label say about paroxetine?
Carvedilol label, drug interactionsInhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (Coreg), Waylis Therapeutics LLC, effective July 31, 2026 (SPL set 07c619c6-4a0c-445e-94fa-664a54f68a39), via openFDA; the full label on DailyMed
What does the paroxetine label say about carvedilol?
Paroxetine's label (effective February 12, 2026) and its 3 other brand-application labels do not name carvedilol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Paroxetine), Mylan Pharmaceuticals Inc., effective February 12, 2026 (SPL set 89dd7e24-85fc-4152-89ea-47ec2b48a1ed), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Carvedilol | Paroxetine | |
|---|---|---|
| Labeled for | Heart failure, High blood pressure | Depression, Anxiety, Menopause symptoms |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0179 per tablet 6.25 mg tablet | $0.0611 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once