Carvedilol and Verapamil Interaction
Drug interaction information between Carvedilol and Verapamil.
Carvedilol and Verapamil have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Carvedilol and Verapamil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medications both work to lower blood pressure and slow the heart. Taking them together can cause an unsafe drop in blood pressure or heart rate.
FDA Label Information
( 7.6 ) Verapamil- or diltiazem-type calcium channel blockers may affect ECG and/or blood pressure. As with other β-blocker, if carvedilol tablet is administered with calcium channel blockers of the verapamil or diltiazem type, it is recommended that ECG and blood pressure be monitored.
Carvedilol Also Interacts With
- Clonidine moderate
- Fluoxetine minor
- Paroxetine minor
- Diltiazem minor
- Fluconazole minor
Verapamil Also Interacts With
- Eplerenone major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Clarithromycin moderate
Frequently Asked Questions
What SPL severity band is on file for Carvedilol + Verapamil?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Verapamil has 57 labeled pairs on file vs Carvedilol's 13. In the minor band specifically: Carvedilol has 12 (also Fluoxetine, Paroxetine, Diltiazem, Fluconazole); Verapamil has 47 (also Atorvastatin, Aspirin, Atenolol, Timolol).
What mechanism field is on file for Carvedilol and Verapamil?
These medications both work to lower blood pressure and slow the heart. Taking them together can cause an unsafe drop in blood pressure or heart rate.
Verapamil carries more major-labeled pairs than Carvedilol
SPL source-record counts only. This page's band is minor · classes on file: Carvedilol (Beta-Blocker (Alpha/Beta)); Verapamil (Calcium Channel Blocker).
Verapamil has 4 major-labeled pairs vs Carvedilol's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 12 minor · 13 total
- Other minor peers for Carvedilol
- Fluoxetine
- Paroxetine
- Diltiazem
- Fluconazole
4 major · 6 moderate · 47 minor · 57 total
- Other minor peers for Verapamil
- Atorvastatin
- Aspirin
- Atenolol
- Timolol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.