Cenobamate and Lamotrigine Interaction
Drug interaction information between Cenobamate and Lamotrigine.
Cenobamate and Lamotrigine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Cenobamate and Lamotrigine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cenobamate speeds up how quickly your body breaks down lamotrigine, which lowers the amount of medicine in your blood. This can make the lamotrigine less effective at preventing seizures.
FDA Label Information
( 7.1 ) Lamotrigine, Carbamazepine: Increase dosage as needed when used concomitantly with XCOPRI. Table 5: Pharmacokinetic Drug Interactions Drug or Substrate Type Effect of XCOPRI on Drug or Substrate Clinical Recommendation Antiepileptic Drugs lamotrigine ↓ plasma concentrations Because of a potential for reduced efficacy of these drugs, increase the dosage of lamotrigine or carbamazepine, as needed, when used concomitantly with XCOPRI.
Cenobamate Also Interacts With
- Phenobarbital moderate
- Clobazam moderate
- Carbamazepine minor
- Phenytoin minor
Lamotrigine Also Interacts With
- Dofetilide moderate
- Desmopressin moderate
- Valproate minor
- Carbamazepine minor
- Rifampin minor
Frequently Asked Questions
What SPL severity band is on file for Cenobamate + Lamotrigine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lamotrigine has 24 labeled pairs on file vs Cenobamate's 5. In the minor band specifically: Cenobamate has 3 (also Carbamazepine, Phenytoin); Lamotrigine has 22 (also Valproate, Carbamazepine, Rifampin, Phenytoin).
What mechanism field is on file for Cenobamate and Lamotrigine?
Cenobamate speeds up how quickly your body breaks down lamotrigine, which lowers the amount of medicine in your blood. This can make the lamotrigine less effective at preventing seizures.
Lamotrigine's labeled portfolio outnumbers Cenobamate
SPL source-record counts only. This page's band is minor · classes on file: Cenobamate (Anticonvulsant); Lamotrigine (Anticonvulsant).
0 major · 2 moderate · 3 minor · 5 total
- Other minor peers for Cenobamate
- Carbamazepine
- Phenytoin
0 major · 2 moderate · 22 minor · 24 total
- Other minor peers for Lamotrigine
- Valproate
- Carbamazepine
- Rifampin
- Phenytoin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.