cenobamate vs clobazam
Side-by-side comparison of cenobamate and clobazam. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
( 7.1 ) Phenobarbital and Clobazam: Reduce dosage as needed when used concomitantly with XCOPRI. phenobarbital ↑ plasma concentrations Because of a potential for an increase in the risk of adverse reactions from these drugs, consider a reduction in dosage of phenobarbital or clobazam, as clinically appropriate, when used concomitantly with XCOPRI. desmethylclobazam, the active metabolite of clobazam ↑ plasma concentrations CYP2B6 Substrates ↓ plasma concentrations Because of a potential for reduced efficacy of these drugs, increase the dosage of CYP2B6 or CYP3A4 substrates, as needed, when...
Recommendation: Your doctor should consider lowering your clobazam dose if you are taking both of these medications.
Xcopri
Onfi, Sympazan
Xcopri is a medicine used to treat partial-onset seizures in adults. It works by reducing the irregular electrical activity in the brain that causes seizures.
Clobazam oral suspension is a medicine used with other medicines to treat seizures caused by Lennox-Gastaut syndrome. It is a type of drug called a benzodiazepine.
Xcopri is used to treat partial-onset seizures in adults. Partial-onset seizures start in one area of the brain. This medicine can help reduce how often you have seizures.
Clobazam oral suspension is used to treat seizures in people 2 years and older who have Lennox-Gastaut syndrome (LGS). LGS is a severe form of epilepsy that begins in childhood. This medicine helps to control seizures when used with other seizure medicines.
Xcopri helps to control seizures by affecting brain activity. It reduces the excitability of brain cells. This helps to prevent the spread of seizure activity.
Clobazam belongs to a class of drugs called benzodiazepines. It works by affecting certain chemicals in the brain that may be unbalanced in people with seizures. This helps to reduce the frequency of seizures.
- • Feeling sleepy
- • Dizziness
- • Feeling tired
- • Double vision
- • Headache
- • Constipation
- • Sleepiness or drowsiness
- • Fever
- • Sluggishness
- • Drooling
- Seizure 1,815
- Tiredness 672
- Sleepiness 660
- Dizziness 537
- Fall 368
- Seizure 4,619
- Sleepiness 1,798
- Medicine interaction 1,123
- Tiredness 1,090
- Epilepsy 805
This medicine can cause a serious allergic reaction called DRESS, which can affect multiple organs. It can also cause liver problems. Tell your doctor right away if you have a fever, rash, swollen lymph nodes, or yellowing of your skin or eyes. Xcopri may cause you to have suicidal thoughts or behaviors. Watch for changes in your mood.
Clobazam can cause serious side effects: * **Risk of Using with Opioids:** Taking clobazam with opioid medicines can cause severe sleepiness, slowed breathing, coma, and death. Only take them together if no other treatment works, and use the lowest dose for the shortest time. * **Risk of Abuse, Misuse, and Addiction:** Clobazam can be abused, misused, and lead to addiction, overdose or death. Your doctor will assess your risk before and during treatment. * **Risk of Dependence and Withdrawal:** Taking clobazam can lead to physical dependence. Stopping it suddenly can cause life-threatening withdrawal symptoms. To stop, your doctor will slowly lower your dose.
Tell your doctor if you are pregnant or plan to become pregnant. Xcopri may harm your unborn baby. There is a pregnancy registry for women who take anti-seizure medicines like Xcopri.
Clobazam may harm your unborn baby. If you are pregnant or plan to become pregnant, talk to your doctor. There is a pregnancy registry for women who take anti-epilepsy drugs like clobazam. You can enroll by calling 1-888-233-2334.
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How to Read This cenobamate vs clobazam Comparison
cenobamate is classified in the Anticonvulsant drug class, while clobazam sits within the Benzodiazepine (Anticonvulsant) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, cenobamate has 4,052 submissions while clobazam has 9,435. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to cenobamate increases the level of the active part of clobazam in your bloodstream. this can lead to more side effects from the clobazam.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between cenobamate and clobazam - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.