Cenobamate and Carbamazepine Interaction
Drug interaction information between Cenobamate and Carbamazepine.
Cenobamate and Carbamazepine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Cenobamate and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cenobamate causes your body to process carbamazepine more quickly, leading to lower levels of the drug in your system. This could mean the medicine will not work as well to control your condition.
FDA Label Information
( 7.1 ) Lamotrigine, Carbamazepine: Increase dosage as needed when used concomitantly with XCOPRI. Table 5: Pharmacokinetic Drug Interactions Drug or Substrate Type Effect of XCOPRI on Drug or Substrate Clinical Recommendation Antiepileptic Drugs lamotrigine ↓ plasma concentrations Because of a potential for reduced efficacy of these drugs, increase the dosage of lamotrigine or carbamazepine, as needed, when used concomitantly with XCOPRI. carbamazepine ↓ plasma concentrations phenytoin ↑ plasma concentrations Because of a potential 2-fold increase in phenytoin levels, gradually decrease...
Cenobamate Also Interacts With
- Phenobarbital moderate
- Clobazam moderate
- Lamotrigine minor
- Phenytoin minor
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Cenobamate + Carbamazepine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Cenobamate's 5. In the minor band specifically: Cenobamate has 3 (also Lamotrigine, Phenytoin); Carbamazepine has 110 (also Omeprazole, Ibuprofen, Citalopram, Amitriptyline).
What mechanism field is on file for Cenobamate and Carbamazepine?
Cenobamate causes your body to process carbamazepine more quickly, leading to lower levels of the drug in your system. This could mean the medicine will not work as well to control your condition.
Carbamazepine carries more major-labeled pairs than Cenobamate
SPL source-record counts only. This page's band is minor · classes on file: Cenobamate (Anticonvulsant); Carbamazepine (Anticonvulsant).
Carbamazepine has 3 major-labeled pairs vs Cenobamate's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 3 minor · 5 total
- Other minor peers for Cenobamate
- Lamotrigine
- Phenytoin
3 major · 16 moderate · 110 minor · 129 total
- Other minor peers for Carbamazepine
- Omeprazole
- Ibuprofen
- Citalopram
- Amitriptyline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.