Cidofovir and Famotidine Interaction
Drug interaction information between Cidofovir and Famotidine.
Cidofovir and Famotidine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Cidofovir and Famotidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Probenecid is used with cidofovir and can change how your kidneys get rid of famotidine. This might cause famotidine to stay in your body longer than usual.
FDA Label Information
Drug Interactions Probenecid Probenecid is known to interact with the metabolism or renal tubular excretion of many drugs (e.g., acetaminophen, acyclovir, angiotensin-converting enzyme inhibitors, aminosalicylic acid, barbiturates, benzodiazepines, bumetanide, clofibrate, methotrexate, famotidine, furosemide, nonsteroidal anti-inflammatory agents, theophylline, and zidovudine).
Cidofovir Also Interacts With
- Vancomycin major
- Gentamicin major
- Tobramycin major
- Amikacin major
- Amphotericin B major
Famotidine Also Interacts With
- Theophylline major
- Tizanidine moderate
- Ketoconazole minor
- Ledipasvir/Sofosbuvir minor
- Itraconazole minor
Frequently Asked Questions
What SPL severity band is on file for Cidofovir + Famotidine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cidofovir has 16 labeled pairs on file vs Famotidine's 11. In the minor band specifically: Cidofovir has 11 (also Furosemide, Acetaminophen, Methotrexate, Acyclovir); Famotidine has 9 (also Ketoconazole, Ledipasvir/Sofosbuvir, Itraconazole, Aripiprazole).
What mechanism field is on file for Cidofovir and Famotidine?
Probenecid is used with cidofovir and can change how your kidneys get rid of famotidine. This might cause famotidine to stay in your body longer than usual.
Cidofovir carries more major-labeled pairs than Famotidine
SPL source-record counts only. This page's band is minor · classes on file: Cidofovir (Antiviral (Nucleotide Analog)); Famotidine (H2 Receptor Antagonist).
Cidofovir has 5 major-labeled pairs vs Famotidine's 1. This page itself is in the minor band, not the major band.
5 major · 0 moderate · 11 minor · 16 total
- Other minor peers for Cidofovir
- Furosemide
- Acetaminophen
- Methotrexate
- Acyclovir
1 major · 1 moderate · 9 minor · 11 total
- Other minor peers for Famotidine
- Ketoconazole
- Ledipasvir/Sofosbuvir
- Itraconazole
- Aripiprazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.