Cidofovir and Acyclovir Interaction
Drug interaction information between Cidofovir and Acyclovir.
Cidofovir and Acyclovir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Cidofovir and Acyclovir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Probenecid is given with cidofovir and can slow down the removal of acyclovir through the kidneys. This can lead to an increase in the amount of acyclovir in your blood.
FDA Label Information
Drug Interactions Probenecid Probenecid is known to interact with the metabolism or renal tubular excretion of many drugs (e.g., acetaminophen, acyclovir, angiotensin-converting enzyme inhibitors, aminosalicylic acid, barbiturates, benzodiazepines, bumetanide, clofibrate, methotrexate, famotidine, furosemide, nonsteroidal anti-inflammatory agents, theophylline, and zidovudine).
Cidofovir Also Interacts With
- Vancomycin major
- Gentamicin major
- Tobramycin major
- Amikacin major
- Amphotericin B major
Acyclovir Also Interacts With
- Bictegravir/Emtricitabine/Tenofovir minor
- Emtricitabine/Tenofovir minor
- Meperidine minor
- Tenofovir Disoproxil minor
- Tizanidine minor
Frequently Asked Questions
What SPL severity band is on file for Cidofovir + Acyclovir?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cidofovir has 16 labeled pairs on file vs Acyclovir's 7. In the minor band specifically: Cidofovir has 11 (also Furosemide, Famotidine, Acetaminophen, Methotrexate); Acyclovir has 7 (also Bictegravir, Emtricitabine/Tenofovir, Meperidine, Tenofovir Disoproxil).
What mechanism field is on file for Cidofovir and Acyclovir?
Probenecid is given with cidofovir and can slow down the removal of acyclovir through the kidneys. This can lead to an increase in the amount of acyclovir in your blood.
Cidofovir carries more major-labeled pairs than Acyclovir
SPL source-record counts only. This page's band is minor · classes on file: Cidofovir (Antiviral (Nucleotide Analog)); Acyclovir (Antiviral (Nucleoside Analog)).
Cidofovir has 5 major-labeled pairs vs Acyclovir's 0. This page itself is in the minor band, not the major band.
5 major · 0 moderate · 11 minor · 16 total
- Other minor peers for Cidofovir
- Furosemide
- Famotidine
- Acetaminophen
- Methotrexate
0 major · 0 moderate · 7 minor · 7 total
- Other minor peers for Acyclovir
- Bictegravir
- Emtricitabine/Tenofovir
- Meperidine
- Tenofovir Disoproxil
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.