Acyclovir and Tenofovir Disoproxil Interaction
Drug interaction information between Acyclovir and Tenofovir Disoproxil.
Acyclovir and Tenofovir Disoproxil have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Acyclovir and Tenofovir Disoproxil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two drugs are both filtered out of the body by the kidneys, which can increase the risk of kidney strain when used at the same time.
FDA Label Information
Some examples include, but are not limited to, acyclovir, cidofovir, ganciclovir, valacyclovir, valganciclovir, aminoglycosides (e.g., gentamicin), and high-dose or multiple NSAIDs [see Warnings and Precautions ( 5.2)].
Acyclovir Also Interacts With
- Bictegravir/Emtricitabine/Tenofovir minor
- Cidofovir minor
- Emtricitabine/Tenofovir minor
- Meperidine minor
- Tizanidine minor
Tenofovir Disoproxil Also Interacts With
- Itraconazole moderate
- Valacyclovir minor
- Gentamicin minor
- Darunavir minor
- Ledipasvir/Sofosbuvir minor
Frequently Asked Questions
What SPL severity band is on file for Acyclovir + Tenofovir Disoproxil?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tenofovir Disoproxil has 14 labeled pairs on file vs Acyclovir's 7. In the minor band specifically: Acyclovir has 7 (also Bictegravir, Cidofovir, Emtricitabine/Tenofovir, Meperidine); Tenofovir Disoproxil has 13 (also Valacyclovir, Gentamicin, Darunavir, Ledipasvir/Sofosbuvir).
What mechanism field is on file for Acyclovir and Tenofovir Disoproxil?
These two drugs are both filtered out of the body by the kidneys, which can increase the risk of kidney strain when used at the same time.
Tenofovir Disoproxil's labeled portfolio outnumbers Acyclovir
SPL source-record counts only. This page's band is minor · classes on file: Acyclovir (Antiviral (Nucleoside Analog)); Tenofovir Disoproxil (Nucleotide Reverse Transcriptase Inhibitor).
0 major · 0 moderate · 7 minor · 7 total
- Other minor peers for Acyclovir
- Bictegravir
- Cidofovir
- Emtricitabine/Tenofovir
- Meperidine
0 major · 1 moderate · 13 minor · 14 total
- Other minor peers for Tenofovir Disoproxil
- Valacyclovir
- Gentamicin
- Darunavir
- Ledipasvir/Sofosbuvir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.