Acyclovir and Meperidine Interaction
Drug interaction information between Acyclovir and Meperidine.
Acyclovir and Meperidine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Acyclovir and Meperidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Acyclovir can cause meperidine and its breakdown products to build up in your blood. This makes the drug's effects stronger and more likely to cause side effects.
FDA Label Information
Acyclovir Clinical Impact: The concomitant use of acyclovir may increase the plasma concentrations of meperidine and its metabolite, normeperidine. Intervention: If concomitant use of acyclovir and Meperidine Hydrochloride Tablets or Oral Solution is necessary, evaluate patients for respiratory depression and sedation at frequent intervals.
Acyclovir Also Interacts With
- Bictegravir/Emtricitabine/Tenofovir minor
- Cidofovir minor
- Emtricitabine/Tenofovir minor
- Tenofovir Disoproxil minor
- Tizanidine minor
Meperidine Also Interacts With
- Safinamide major
- Rasagiline moderate
- Tranylcypromine moderate
- Gabapentin minor
- Trazodone minor
Frequently Asked Questions
What SPL severity band is on file for Acyclovir + Meperidine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Meperidine has 31 labeled pairs on file vs Acyclovir's 7. In the minor band specifically: Acyclovir has 7 (also Bictegravir, Cidofovir, Emtricitabine/Tenofovir, Tenofovir Disoproxil); Meperidine has 28 (also Gabapentin, Trazodone, Tramadol, Cyclobenzaprine).
What mechanism field is on file for Acyclovir and Meperidine?
Acyclovir can cause meperidine and its breakdown products to build up in your blood. This makes the drug's effects stronger and more likely to cause side effects.
Meperidine carries more major-labeled pairs than Acyclovir
SPL source-record counts only. This page's band is minor · classes on file: Acyclovir (Antiviral (Nucleoside Analog)); Meperidine (Opioid Analgesic).
Meperidine has 1 major-labeled pair vs Acyclovir's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 7 minor · 7 total
- Other minor peers for Acyclovir
- Bictegravir
- Cidofovir
- Emtricitabine/Tenofovir
- Tenofovir Disoproxil
1 major · 2 moderate · 28 minor · 31 total
- Other minor peers for Meperidine
- Gabapentin
- Trazodone
- Tramadol
- Cyclobenzaprine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.