Acyclovir and Emtricitabine/Tenofovir Interaction
Drug interaction information between Acyclovir and Emtricitabine/Tenofovir.
Acyclovir and Emtricitabine/Tenofovir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Acyclovir and Emtricitabine/Tenofovir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medicines are cleared from the body using the same pathway in the kidneys, which can lead to higher levels of the drugs in your system.
FDA Label Information
Some examples include, but are not limited to, acyclovir, adefovir dipivoxil, cidofovir, ganciclovir, valacyclovir, valganciclovir, aminoglycosides (e.g., gentamicin), and high-dose or multiple NSAIDs [see Warnings and Precautions (5.3) ] .
Acyclovir Also Interacts With
- Bictegravir/Emtricitabine/Tenofovir minor
- Cidofovir minor
- Meperidine minor
- Tenofovir Disoproxil minor
- Tizanidine minor
Emtricitabine/Tenofovir Also Interacts With
- Valacyclovir minor
- Gentamicin minor
- Tenofovir Disoproxil minor
- Darunavir minor
- Ledipasvir/Sofosbuvir minor
Frequently Asked Questions
What SPL severity band is on file for Acyclovir + Emtricitabine/Tenofovir?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Emtricitabine/Tenofovir has 9 labeled pairs on file vs Acyclovir's 7. In the minor band specifically: Acyclovir has 7 (also Bictegravir, Cidofovir, Meperidine, Tenofovir Disoproxil); Emtricitabine/Tenofovir has 9 (also Valacyclovir, Gentamicin, Tenofovir Disoproxil, Darunavir).
What mechanism field is on file for Acyclovir and Emtricitabine/Tenofovir?
These medicines are cleared from the body using the same pathway in the kidneys, which can lead to higher levels of the drugs in your system.
Emtricitabine/Tenofovir's labeled portfolio outnumbers Acyclovir
SPL source-record counts only. This page's band is minor · classes on file: Acyclovir (Antiviral (Nucleoside Analog)); Emtricitabine/Tenofovir (NRTI Combination (HIV PrEP)).
0 major · 0 moderate · 7 minor · 7 total
- Other minor peers for Acyclovir
- Bictegravir
- Cidofovir
- Meperidine
- Tenofovir Disoproxil
0 major · 0 moderate · 9 minor · 9 total
- Other minor peers for Emtricitabine/Tenofovir
- Valacyclovir
- Gentamicin
- Tenofovir Disoproxil
- Darunavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.