Cholestyramine and Amiodarone Interaction
Drug interaction information between Cholestyramine and Amiodarone.
Cholestyramine and Amiodarone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Cholestyramine and Amiodarone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cholestyramine can bind to amiodarone in the digestive tract and prevent it from being absorbed into the blood. This lowers the amount of medicine available to help your heart.
FDA Label Information
Cholestyramine Reduced amiodarone serum levels.
Cholestyramine Also Interacts With
- Naproxen moderate
- Olmesartan moderate
- Raloxifene moderate
- Propranolol minor
- Warfarin minor
Amiodarone Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir major
- Simvastatin major
- Lithium moderate
Frequently Asked Questions
What SPL severity band is on file for Cholestyramine + Amiodarone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amiodarone has 42 labeled pairs on file vs Cholestyramine's 34. In the minor band specifically: Cholestyramine has 31 (also Propranolol, Warfarin, Tetracycline, Phenobarbital); Amiodarone has 29 (also Atorvastatin, Clonidine, Diltiazem, Verapamil).
What mechanism field is on file for Cholestyramine and Amiodarone?
Cholestyramine can bind to amiodarone in the digestive tract and prevent it from being absorbed into the blood. This lowers the amount of medicine available to help your heart.
Amiodarone carries more major-labeled pairs than Cholestyramine
SPL source-record counts only. This page's band is minor · classes on file: Cholestyramine (Bile Acid Sequestrant); Amiodarone (Class III Antiarrhythmic).
Amiodarone has 4 major-labeled pairs vs Cholestyramine's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 31 minor · 34 total
- Other minor peers for Cholestyramine
- Propranolol
- Warfarin
- Tetracycline
- Phenobarbital
4 major · 9 moderate · 29 minor · 42 total
- Other minor peers for Amiodarone
- Atorvastatin
- Clonidine
- Diltiazem
- Verapamil
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.