Cholestyramine and Propranolol Interaction
Drug interaction information between Cholestyramine and Propranolol.
Cholestyramine and Propranolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Cholestyramine and Propranolol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cholestyramine can bind to propranolol in your gut and prevent it from entering your bloodstream. This means you might not get the full effect of the propranolol.
FDA Label Information
Drug Interactions Cholestyramine resin may delay or reduce the absorption of concomitant oral medication such as phenylbutazone, warfarin, thiazide diuretics (acidic) or propranolol (basic), as well as tetracycline, penicillin G, phenobarbital, thyroid and thyroxine preparations, estrogens and progestins and digitalis.
Cholestyramine Also Interacts With
- Naproxen moderate
- Olmesartan moderate
- Raloxifene moderate
- Warfarin minor
- Tetracycline minor
Frequently Asked Questions
What SPL severity band is on file for Cholestyramine + Propranolol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Propranolol has 44 labeled pairs on file vs Cholestyramine's 34. In the minor band specifically: Cholestyramine has 31 (also Warfarin, Tetracycline, Phenobarbital, Amiodarone); Propranolol has 44 (also Clonidine, Diltiazem, Warfarin, Verapamil).
What mechanism field is on file for Cholestyramine and Propranolol?
Cholestyramine can bind to propranolol in your gut and prevent it from entering your bloodstream. This means you might not get the full effect of the propranolol.
Propranolol's labeled portfolio outnumbers Cholestyramine
SPL source-record counts only. This page's band is minor · classes on file: Cholestyramine (Bile Acid Sequestrant); Propranolol (Non-Selective Beta-Blocker).
0 major · 3 moderate · 31 minor · 34 total
- Other minor peers for Cholestyramine
- Warfarin
- Tetracycline
- Phenobarbital
- Amiodarone
0 major · 0 moderate · 44 minor · 44 total
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.