Cholestyramine and Raloxifene Interaction
Drug interaction information between Cholestyramine and Raloxifene.
Cholestyramine and Raloxifene have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Cholestyramine and Raloxifene. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cholestyramine can stick to other medicines in your digestive tract and prevent them from being absorbed into your body. This makes the other medicine, like raloxifene, much less effective.
FDA Label Information
7 DRUG INTERACTIONS Cholestyramine : Use with raloxifene hydrochloride is not recommended. (7.3 , 12.3) 7.1 Cholestyramine Concomitant administration of cholestyramine with raloxifene hydrochloride is not recommended.
Cholestyramine Also Interacts With
- Naproxen moderate
- Olmesartan moderate
- Propranolol minor
- Warfarin minor
- Tetracycline minor
Raloxifene Also Interacts With
- Diazepam moderate
- Diazoxide moderate
- Amoxicillin minor
- Warfarin minor
- Digoxin minor
Frequently Asked Questions
What SPL severity band is on file for Cholestyramine + Raloxifene?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cholestyramine has 34 labeled pairs on file vs Raloxifene's 7. In the moderate band specifically: Cholestyramine has 3 (also Naproxen, Olmesartan); Raloxifene has 3 (also Diazepam, Diazoxide).
What mechanism field is on file for Cholestyramine and Raloxifene?
Cholestyramine can stick to other medicines in your digestive tract and prevent them from being absorbed into your body. This makes the other medicine, like raloxifene, much less effective.
Cholestyramine's labeled portfolio outnumbers Raloxifene
SPL source-record counts only. This page's band is moderate · classes on file: Cholestyramine (Bile Acid Sequestrant); Raloxifene (Selective Estrogen Receptor Modulator (SERM)).
0 major · 3 moderate · 31 minor · 34 total
- Other moderate peers for Cholestyramine
- Naproxen
- Olmesartan
0 major · 3 moderate · 4 minor · 7 total
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.