chlorpromazine vs tranylcypromine
Side-by-side comparison of chlorpromazine and tranylcypromine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
Product Clinical Comment on Concomitant Use [See Contraindications (4.1)] ; Predominant Effect/Risk [Hypertensive Reaction (HR) [See Warnings and Precautions (5.3)] ; or Serotonin Syndrome (SS) [See Warnings and Precautions (5.7)] ] Altretamine Use with caution If not otherwise specified in this table, consider avoiding concomitant use (see also information on medication-free intervals , use agent at the lowest appropriate dose, monitor for effects of the interaction, advise the patient to report potential effects, and be prepared to discontinue the agent and treat effects of the...
Recommendation: Consider avoiding this combination if possible. If you must take both, your doctor should monitor your blood pressure and mental state very carefully for any signs of a reaction.
Thorazine
Parnate
Chlorpromazine is a medicine that belongs to a class of drugs called phenothiazine antipsychotics. It can help manage symptoms of certain mental disorders by affecting chemical messengers in the brain.
Tranylcypromine (Parnate) is a medicine used to treat major depression in adults. It is used when other antidepressants have not worked well enough.
Chlorpromazine can treat psychotic disorders like schizophrenia. It can also control nausea and vomiting. Additionally, it can help with restlessness before surgery, acute intermittent porphyria, tetanus, manic episodes of bipolar disorder, and intractable hiccups. In children, it can treat severe behavioral problems and hyperactivity.
Tranylcypromine is used to treat major depressive disorder (MDD) in adults. You should only use it if other antidepressants haven't helped. It is not for the first treatment of depression because it can cause serious side effects and has many drug and food interactions.
Chlorpromazine works by changing the effect of certain natural chemicals in the brain. It blocks dopamine receptors, which helps to reduce psychotic symptoms. It also affects other neurotransmitters, such as histamine and acetylcholine.
Tranylcypromine belongs to a class of drugs called MAO inhibitors. It works by increasing the levels of certain chemicals in your brain. These chemicals can help improve your mood.
- • Drowsiness
- • Dry mouth
- • Dizziness
- • Trouble sleeping
- • Feeling sleepy
- • Headache
- Harmful effects from different substances 426
- Taking too much medicine 345
- Medicines affecting each other 322
- A severe reaction to antipsychotic drugs causing fever, muscle stiffness, and altered mental status 280
- Feeling sick to your stomach 272
- Interaction between medicines 68
- Feeling sad or hopeless 36
- Too much serotonin in the body 27
- Head pain 24
- High blood pressure 24
Antipsychotic medicines like chlorpromazine can increase the risk of death in elderly patients who have dementia-related psychosis. Chlorpromazine is not approved for treating this condition.
Tranylcypromine can increase the risk of suicidal thoughts and behaviors in young adults. It can also cause a dangerous increase in blood pressure if you eat foods high in tyramine or take certain medicines. Make sure to follow all food and drug restrictions.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if chlorpromazine will harm your unborn baby. Talk to your doctor about the risks and benefits of taking this medicine during pregnancy and breastfeeding.
There is limited information about the safety of tranylcypromine during pregnancy. Talk to your doctor if you are pregnant or plan to become pregnant. It is not recommended to breastfeed while taking this medicine because it can harm the baby.
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How to Read This chlorpromazine vs tranylcypromine Comparison
chlorpromazine is classified in the Typical Antipsychotic (Phenothiazine) drug class, while tranylcypromine sits within the Monoamine Oxidase Inhibitor (MAOI) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, chlorpromazine has 1,645 submissions while tranylcypromine has 179. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to these drugs can interact to cause dangerously high blood pressure or a life-threatening reaction involving too much serotonin in the brain. they both impact the way your body regulates mood and blood vessel health.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between chlorpromazine and tranylcypromine - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.