What the FDA labels say about taking them together
Carvedilol and clonidine
Carvedilol's FDA label of July 31, 2026 names clonidine in its drug interactions section; clonidine's label does not name carvedilol itself but warns about its class (Beta blockers). The carvedilol label: “DRUG INTERACTIONS CYP P450 2D6 enzyme inhibitors may increase and rifampin may decrease carvedilol levels. Hypotensive agents may increase the risk of hypotension and/or severe bradycardia. …”
Check it at the source: the carvedilol FDA label on DailyMed (effective July 31, 2026, Waylis Therapeutics LLC); the clonidine FDA label on DailyMed (effective March 30, 2026, Unichem Pharmaceuticals (USA), Inc.).
What does the carvedilol label say about clonidine?
Carvedilol label, drug interactionsDRUG INTERACTIONS CYP P450 2D6 enzyme inhibitors may increase and rifampin may decrease carvedilol levels. ( 7.1 , 7.5 ) Hypotensive agents (e.g., reserpine, MAO inhibitors, clonidine) may increase the risk of hypotension and/or severe bradycardia. ( 7.4 ) Cyclosporine or digoxin levels may increase. ( 7.3 , 7.4 ) Both digitalis glycosides and β-blockers slow atrioventricular conduction and decrease heart rate.
Source: FDA drug label (Coreg Cr, NDA022012), Waylis Therapeutics LLC, effective April 25, 2025 (SPL set d3625d78-6eb6-41fe-8f6f-664965c104c4), via openFDA
Source: FDA drug label (Coreg), Waylis Therapeutics LLC, effective July 31, 2026 (SPL set 07c619c6-4a0c-445e-94fa-664a54f68a39), via openFDA; the full label on DailyMed
What does the clonidine label say about carvedilol?
Clonidine's label does not name carvedilol itself; it warns about its class (Beta blockers):
Clonidine label, drug interactionsMonitor heart rate in patients receiving clonidine concomitantly with agents known to affect sinus node function or AV nodal conduction, e.g. , digitalis, calcium channel blockers and beta-blockers.
Clonidine label, warningsThe likelihood of such reactions to discontinuation of clonidine therapy appears to be greater after administration of higher doses or continuation of concomitant beta-blocker treatment and special caution is therefore advised in these situations.
Source: FDA drug label (clonidine hydrochloride), Unichem Pharmaceuticals (USA), Inc., effective March 30, 2026 (SPL set 21bfa28f-20df-43fd-bb80-b720d3b40696), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Carvedilol | Clonidine | |
|---|---|---|
| Labeled for | Heart failure, High blood pressure | High blood pressure, ADHD, Pain |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0179 per tablet 6.25 mg tablet | $0.0241 per tablet 0.1 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once