Budesonide and Darunavir Interaction
Drug interaction information between Budesonide and Darunavir.
Budesonide and Darunavir have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Budesonide and Darunavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir prevents the body from clearing budesonide, which can lead to very high steroid levels in the blood. This increases the risk of your adrenal glands not working properly.
FDA Label Information
betamethasone budesonide ciclesonide fluticasone methylprednisolone mometasone triamcinolone ↑ corticosteroids Co-administration with corticosteroids (all routes of administration) of which exposures are significantly increased by strong CYP3A inhibitors can increase the risk for Cushing's syndrome and adrenal suppression.
Budesonide Also Interacts With
- Nirmatrelvir/Ritonavir moderate
- Budesonide/Formoterol minor
- Itraconazole minor
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Budesonide + Darunavir?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Budesonide's 4. In the moderate band specifically: Budesonide has 2 (also Nirmatrelvir/Ritonavir); Darunavir has 16 (also Omeprazole, Fluticasone, Apixaban, Clopidogrel).
What mechanism field is on file for Budesonide and Darunavir?
Darunavir prevents the body from clearing budesonide, which can lead to very high steroid levels in the blood. This increases the risk of your adrenal glands not working properly.
Darunavir carries more major-labeled pairs than Budesonide
SPL source-record counts only. This page's band is moderate · classes on file: Budesonide (Corticosteroid); Darunavir (HIV Protease Inhibitor).
Darunavir has 15 major-labeled pairs vs Budesonide's 0. This page itself is in the moderate band, not the major band.
0 major · 2 moderate · 2 minor · 4 total
- Other moderate peers for Budesonide
- Nirmatrelvir/Ritonavir
15 major · 16 moderate · 70 minor · 101 total
- Other moderate peers for Darunavir
- Omeprazole
- Fluticasone
- Apixaban
- Clopidogrel
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.