Budesonide and Nirmatrelvir/Ritonavir Interaction
Drug interaction information between Budesonide and Nirmatrelvir/Ritonavir.
Budesonide and Nirmatrelvir/Ritonavir have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Budesonide and Nirmatrelvir/Ritonavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
The antiviral blocks the natural process your body uses to get rid of budesonide, causing the steroid levels to rise. This can lead to serious side effects like hormone imbalances and adrenal suppression.
FDA Label Information
Corticosteroids primarily metabolized by CYP3A betamethasone, budesonide, ciclesonide, dexamethasone, fluticasone, methylprednisolone, mometasone, triamcinolone ↑ corticosteroid Co-administration with corticosteroids (all routes of administration) of which exposures are significantly increased by strong CYP3A inhibitors can increase the risk for Cushing’s syndrome and adrenal suppression.
Budesonide Also Interacts With
- Darunavir moderate
- Budesonide/Formoterol minor
- Itraconazole minor
Nirmatrelvir/Ritonavir Also Interacts With
- Simvastatin major
- Lovastatin major
- Sildenafil major
- Carbamazepine major
- Rifampin major
Frequently Asked Questions
What SPL severity band is on file for Budesonide + Nirmatrelvir/Ritonavir?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Nirmatrelvir/Ritonavir has 86 labeled pairs on file vs Budesonide's 4. In the moderate band specifically: Budesonide has 2 (also Darunavir); Nirmatrelvir/Ritonavir has 30 (also Amlodipine, Tamsulosin, Fluticasone, Apixaban).
What mechanism field is on file for Budesonide and Nirmatrelvir/Ritonavir?
The antiviral blocks the natural process your body uses to get rid of budesonide, causing the steroid levels to rise. This can lead to serious side effects like hormone imbalances and adrenal suppression.
Nirmatrelvir/Ritonavir carries more major-labeled pairs than Budesonide
SPL source-record counts only. This page's band is moderate · classes on file: Budesonide (Corticosteroid); Nirmatrelvir/Ritonavir (Antiviral (Protease Inhibitor Combination)).
Nirmatrelvir/Ritonavir has 23 major-labeled pairs vs Budesonide's 0. This page itself is in the moderate band, not the major band.
23 major · 30 moderate · 33 minor · 86 total
- Other moderate peers for Nirmatrelvir/Ritonavir
- Amlodipine
- Tamsulosin
- Fluticasone
- Apixaban
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.