Benazepril and Amlodipine/Benazepril Interaction
Drug interaction information between Benazepril and Amlodipine/Benazepril.
Benazepril and Amlodipine/Benazepril have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Benazepril and Amlodipine/Benazepril. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking both of these medications means you are taking the same medicine twice. This can lead to a higher risk of kidney problems or dangerously low blood pressure.
FDA Label Information
Benazepril Potassium Supplements and Potassium-Sparing Diuretics: Benazepril can attenuate potassium loss caused by thiazide diuretics. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors): In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including benazepril, may result in deterioration of renal function, including possible acute renal failure. Monitor renal function...
Benazepril Also Interacts With
- Aliskiren major
- Spironolactone moderate
- Lithium moderate
- Amiloride moderate
Amlodipine/Benazepril Also Interacts With
- Amlodipine major
- Simvastatin major
- Lithium major
- Aliskiren major
- Spironolactone moderate
Frequently Asked Questions
What SPL severity band is on file for Benazepril + Amlodipine/Benazepril?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amlodipine/Benazepril has 7 labeled pairs on file vs Benazepril's 5. In the minor band specifically: Benazepril has 1; Amlodipine/Benazepril has 1.
What mechanism field is on file for Benazepril and Amlodipine/Benazepril?
Taking both of these medications means you are taking the same medicine twice. This can lead to a higher risk of kidney problems or dangerously low blood pressure.
Amlodipine/Benazepril carries more major-labeled pairs than Benazepril
SPL source-record counts only. This page's band is minor · classes on file: Benazepril (ACE Inhibitor); Amlodipine/Benazepril (Calcium Channel Blocker / ACE Inhibitor Combination).
Amlodipine/Benazepril has 4 major-labeled pairs vs Benazepril's 1. This page itself is in the minor band, not the major band.
1 major · 3 moderate · 1 minor · 5 total
Benazepril has no other minor-band peer in this dataset besides Amlodipine/Benazepril.
4 major · 2 moderate · 1 minor · 7 total
Amlodipine/Benazepril has no other minor-band peer in this dataset besides Benazepril.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.