Benazepril and Amlodipine/Benazepril Interaction
Drug interaction information between Benazepril and Amlodipine/Benazepril.
Benazepril and Amlodipine/Benazepril have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Benazepril and Amlodipine/Benazepril. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Taking both of these medications means you are taking the same medicine twice. This can lead to a higher risk of kidney problems or dangerously low blood pressure.
What To Do
Avoid taking these together because they contain the same active ingredient. Your doctor should review your medications to ensure you are on the correct dose.
FDA Label Information
Benazepril Potassium Supplements and Potassium-Sparing Diuretics: Benazepril can attenuate potassium loss caused by thiazide diuretics. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors): In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including benazepril, may result in deterioration of renal function, including possible acute renal failure. Monitor renal function...
Benazepril Also Interacts With
- Aliskiren major
- Spironolactone moderate
- Lithium moderate
- Amiloride moderate
Amlodipine/Benazepril Also Interacts With
- Amlodipine major
- Simvastatin major
- Lithium major
- Aliskiren major
- Spironolactone moderate
Frequently Asked Questions
Can I take Benazepril and Amlodipine/Benazepril together?
This is a minor interaction. Avoid taking these together because they contain the same active ingredient. Your doctor should review your medications to ensure you are on the correct dose.
How serious is the interaction between Benazepril and Amlodipine/Benazepril?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Benazepril and Amlodipine/Benazepril interact?
Taking both of these medications means you are taking the same medicine twice. This can lead to a higher risk of kidney problems or dangerously low blood pressure.
Understanding the Benazepril and Amlodipine/Benazepril Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Benazepril belongs to the ACE Inhibitor class and Amlodipine/Benazepril belongs to the Calcium Channel Blocker / ACE Inhibitor Combination class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Taking both of these medications means you are taking the same medicine twice. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Benazepril has 5 total documented interactions on file in this dataset, and Amlodipine/Benazepril has 7. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Avoid taking these together because they contain the same active ingredient. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Benazepril or Amlodipine/Benazepril based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.