Benazepril and Lithium Interaction
Drug interaction information between Benazepril and Lithium.
Benazepril and Lithium have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Benazepril and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Benazepril can make it harder for your kidneys to remove lithium from your body. This causes lithium to build up to levels that can be poisonous.
FDA Label Information
7 DRUG INTERACTIONS • Diuretics: Excessive drop in blood pressure ( 7.1 ) • Antidiabetics: Increased risk of hypoglycaemia ( 7.2 ) • NSAIDS: Increased risk of renal impairment and loss of antihypertensive efficacy ( 7.3 ) • Dual inhibition of the renin-angiotensin system: Increased risk of renal impairment, hypotension and hyperkalemia ( 7.4 ) • Lithium: Symptoms of lithium toxicity ( 7.6 ) • Neprilysin Inhibitor: Increased risk of angioedema ( Error! 7.6 Lithium Lithium toxicity has been reported in patients receiving lithium concomitantly with benazepril hydrochloride. Lithium toxicity...
Benazepril Also Interacts With
- Aliskiren major
- Spironolactone moderate
- Amiloride moderate
- Amlodipine/Benazepril minor
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Benazepril + Lithium?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Benazepril's 5. In the moderate band specifically: Benazepril has 3 (also Spironolactone, Amiloride); Lithium has 23 (also Amiloride, Amiodarone, Amlodipine/Valsartan, Azilsartan).
What mechanism field is on file for Benazepril and Lithium?
Benazepril can make it harder for your kidneys to remove lithium from your body. This causes lithium to build up to levels that can be poisonous.
Lithium carries more major-labeled pairs than Benazepril
SPL source-record counts only. This page's band is moderate · classes on file: Benazepril (ACE Inhibitor); Lithium (Mood Stabilizer).
Lithium has 2 major-labeled pairs vs Benazepril's 1. This page itself is in the moderate band, not the major band.
1 major · 3 moderate · 1 minor · 5 total
- Other moderate peers for Benazepril
- Spironolactone
- Amiloride
2 major · 23 moderate · 65 minor · 90 total
- Other moderate peers for Lithium
- Amiloride
- Amiodarone
- Amlodipine/Valsartan
- Azilsartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.