Benazepril and Amiloride Interaction
Drug interaction information between Benazepril and Amiloride.
Benazepril and Amiloride have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Benazepril and Amiloride. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two drugs both prevent the kidneys from flushing out potassium. Taking them together increases the risk that your potassium levels will become too high.
FDA Label Information
Hyperkalemia Potassium-sparing diuretics (spironolactone, amiloride, triamterene, and others) can increase the risk of hyperkalemia.
Benazepril Also Interacts With
- Aliskiren major
- Spironolactone moderate
- Lithium moderate
- Amlodipine/Benazepril minor
Amiloride Also Interacts With
- Potassium Chloride major
- Cyclosporine moderate
- Lithium moderate
- Amlodipine/Benazepril moderate
- Perindopril moderate
Frequently Asked Questions
What SPL severity band is on file for Benazepril + Amiloride?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amiloride has 19 labeled pairs on file vs Benazepril's 5. In the moderate band specifically: Benazepril has 3 (also Spironolactone, Lithium); Amiloride has 7 (also Cyclosporine, Lithium, Amlodipine/Benazepril, Perindopril).
What mechanism field is on file for Benazepril and Amiloride?
These two drugs both prevent the kidneys from flushing out potassium. Taking them together increases the risk that your potassium levels will become too high.
Amiloride's labeled portfolio outnumbers Benazepril
SPL source-record counts only. This page's band is moderate · classes on file: Benazepril (ACE Inhibitor); Amiloride (Potassium-Sparing Diuretic).
1 major · 3 moderate · 1 minor · 5 total
- Other moderate peers for Benazepril
- Spironolactone
- Lithium
1 major · 7 moderate · 11 minor · 19 total
- Other moderate peers for Amiloride
- Cyclosporine
- Lithium
- Amlodipine/Benazepril
- Perindopril
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.