Amlodipine/Benazepril and Simvastatin Interaction
Drug interaction information between Amlodipine/Benazepril and Simvastatin.
Amlodipine/Benazepril and Simvastatin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Amlodipine/Benazepril and Simvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
The amlodipine in this combination pill increases the amount of simvastatin that stays in your bloodstream.
FDA Label Information
7 DRUG INTERACTIONS • Potassium supplements/potassium-sparing diuretics: hyperkalemia ( 7.1 ) • Lithium: Increased serum lithium levels; toxicity symptoms ( 7.1 ) • Injectable gold: facial flushing, nausea, vomiting, hypotension ( 7.1 ) • Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Risk of renal dysfunction, loss of antihypertensive effect ( 7.1 ) • Do not exceed doses greater than 20 mg daily of simvastatin ( 7.1 ) • mTOR inhibitors: increased risk of angioedema ( 7.1 ) • Dual inhibition of the RAS: Increased risk of renal impairment, hypotension, and hyperkalemia ( 7.1 ) • Neprilysin...
Amlodipine/Benazepril Also Interacts With
- Amlodipine major
- Lithium major
- Aliskiren major
- Spironolactone moderate
- Amiloride moderate
Simvastatin Also Interacts With
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
- Dronedarone major
Frequently Asked Questions
What SPL severity band is on file for Amlodipine/Benazepril + Simvastatin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Simvastatin has 41 labeled pairs on file vs Amlodipine/Benazepril's 7. In the major band specifically: Amlodipine/Benazepril has 4 (also Amlodipine, Lithium, Aliskiren); Simvastatin has 11 (also Diltiazem, Verapamil, Cyclosporine, Amiodarone).
What mechanism field is on file for Amlodipine/Benazepril and Simvastatin?
The amlodipine in this combination pill increases the amount of simvastatin that stays in your bloodstream.
Simvastatin carries more major-labeled pairs than Amlodipine/Benazepril
SPL source-record counts only. This page's band is major · classes on file: Amlodipine/Benazepril (Calcium Channel Blocker / ACE Inhibitor Combination); Simvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Simvastatin has 11 major-labeled pairs vs Amlodipine/Benazepril's 4.
4 major · 2 moderate · 1 minor · 7 total
- Other major peers for Amlodipine/Benazepril
- Amlodipine
- Lithium
- Aliskiren
11 major · 9 moderate · 21 minor · 41 total
- Other major peers for Simvastatin
- Diltiazem
- Verapamil
- Cyclosporine
- Amiodarone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.