Benazepril and Spironolactone Interaction
Drug interaction information between Benazepril and Spironolactone.
Benazepril and Spironolactone have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Benazepril and Spironolactone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medicines cause the body to hold onto potassium instead of getting rid of it through urine. This can lead to a dangerous buildup of potassium in your blood.
FDA Label Information
Hyperkalemia Potassium-sparing diuretics (spironolactone, amiloride, triamterene, and others) can increase the risk of hyperkalemia.
Benazepril Also Interacts With
- Aliskiren major
- Lithium moderate
- Amiloride moderate
- Amlodipine/Benazepril minor
Spironolactone Also Interacts With
- Lithium moderate
- Trimethoprim moderate
- Heparin moderate
- Amlodipine/Benazepril moderate
- Lovastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Benazepril + Spironolactone?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Spironolactone has 23 labeled pairs on file vs Benazepril's 5. In the moderate band specifically: Benazepril has 3 (also Lithium, Amiloride); Spironolactone has 9 (also Lithium, Trimethoprim, Heparin, Amlodipine/Benazepril).
What mechanism field is on file for Benazepril and Spironolactone?
Both of these medicines cause the body to hold onto potassium instead of getting rid of it through urine. This can lead to a dangerous buildup of potassium in your blood.
Benazepril carries more major-labeled pairs than Spironolactone
SPL source-record counts only. This page's band is moderate · classes on file: Benazepril (ACE Inhibitor); Spironolactone (Potassium-Sparing Diuretic / Aldosterone Antagonist).
Benazepril has 1 major-labeled pair vs Spironolactone's 0. This page itself is in the moderate band, not the major band.
1 major · 3 moderate · 1 minor · 5 total
0 major · 9 moderate · 14 minor · 23 total
- Other moderate peers for Spironolactone
- Lithium
- Trimethoprim
- Heparin
- Amlodipine/Benazepril
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.