Benazepril and Spironolactone Interaction
Drug interaction information between Benazepril and Spironolactone.
Benazepril and Spironolactone have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Benazepril and Spironolactone. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Both of these medicines cause the body to hold onto potassium instead of getting rid of it through urine. This can lead to a dangerous buildup of potassium in your blood.
What To Do
Your doctor should monitor your blood potassium levels closely while you are taking this combination.
FDA Label Information
Hyperkalemia Potassium-sparing diuretics (spironolactone, amiloride, triamterene, and others) can increase the risk of hyperkalemia.
Benazepril Also Interacts With
- Aliskiren major
- Lithium moderate
- Amiloride moderate
- Amlodipine/Benazepril minor
Spironolactone Also Interacts With
- Lithium moderate
- Trimethoprim moderate
- Heparin moderate
- Amlodipine/Benazepril moderate
- Lovastatin moderate
Frequently Asked Questions
Can I take Benazepril and Spironolactone together?
This is a moderate interaction. Your doctor should monitor your blood potassium levels closely while you are taking this combination.
How serious is the interaction between Benazepril and Spironolactone?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Benazepril and Spironolactone interact?
Both of these medicines cause the body to hold onto potassium instead of getting rid of it through urine. This can lead to a dangerous buildup of potassium in your blood.
Understanding the Benazepril and Spironolactone Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Benazepril belongs to the ACE Inhibitor class and Spironolactone belongs to the Potassium-Sparing Diuretic / Aldosterone Antagonist class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Both of these medicines cause the body to hold onto potassium instead of getting rid of it through urine. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Benazepril has 5 total documented interactions on file in this dataset, and Spironolactone has 23. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should monitor your blood potassium levels closely while you are taking this combination. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Benazepril or Spironolactone based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.