amlodipine/benazepril vs benazepril
Side-by-side comparison of amlodipine/benazepril and benazepril. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Benazepril Potassium Supplements and Potassium-Sparing Diuretics: Benazepril can attenuate potassium loss caused by thiazide diuretics. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors): In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including benazepril, may result in deterioration of renal function, including possible acute renal failure. Monitor renal function...
Recommendation: Avoid taking these together because they contain the same active ingredient. Your doctor should review your medications to ensure you are on the correct dose.
Lotrel
Lotensin
Lotrel is a combination medicine that contains amlodipine and benazepril. It is used to treat high blood pressure.
Benazepril (Lotensin) is a medicine that lowers your blood pressure. Lowering blood pressure helps to prevent strokes and heart attacks.
Lotrel is used to treat high blood pressure. It is for people whose blood pressure is not controlled well enough with just one medicine (either amlodipine or benazepril alone). This medicine helps to lower blood pressure, which can reduce the risk of strokes and heart attacks.
Benazepril is used to treat high blood pressure (hypertension). Lowering your blood pressure reduces your risk of heart attack and stroke. It can be used alone or with other blood pressure medicines.
Lotrel contains two medicines that work in different ways to lower blood pressure. Amlodipine relaxes and widens blood vessels so blood can flow more easily. Benazepril lowers blood pressure by preventing your body from making a substance that narrows blood vessels.
Benazepril is an ACE inhibitor. It works by relaxing your blood vessels. This makes it easier for your heart to pump blood.
- • Cough
- • Headache
- • Dizziness
- • Swelling (edema)
- • Headache
- • Dizziness
- • Feeling sleepy
- • Dizziness when standing up
- Tiredness 15,696
- Diarrhea 14,038
- Feeling sick to your stomach 13,425
- Shortness of breath 13,222
- Feeling lightheaded 10,671
- Feeling sick to your stomach 439
- Feeling tired 408
- Feeling lightheaded 382
- Difficulty breathing 380
- Discomfort 361
This medicine can harm your unborn baby or cause death. If you become pregnant, stop taking Lotrel and tell your doctor right away.
If you become pregnant, stop taking benazepril right away and tell your doctor. This medicine can harm or kill your unborn baby.
Do not take Lotrel if you are pregnant. It can cause serious harm to your unborn baby, especially during the second and third trimesters. If you are breastfeeding, talk to your doctor before taking this medicine.
Benazepril can cause serious harm to your unborn baby, including death. Stop taking it as soon as you know you are pregnant. Talk to your doctor about other blood pressure medicines if you are planning to become pregnant.
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How to Read This amlodipine/benazepril vs benazepril Comparison
amlodipine/benazepril is classified in the Calcium Channel Blocker / ACE Inhibitor Combination drug class, while benazepril sits within the ACE Inhibitor class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, amlodipine/benazepril has 67,052 submissions while benazepril has 1,970. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to taking both of these medications means you are taking the same medicine twice. this can lead to a higher risk of kidney problems or dangerously low blood pressure.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between amlodipine/benazepril and benazepril - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.