Prescription medication · ACE Inhibitor
benazepril
Also sold as Lotensin. Benazepril is used to treat high blood pressure (hypertension).
Data updated 2026-05-15
- 7,061
- FDA reportsLightly reported
- 5
- InteractionsFew interactions
- $0.05
- Generic price (NADAC)
What the data shows
benazepril (Lotensin) is a prescription ACE Inhibitor, reported less often than most tracked drugs (7,061 FDA reports), with 5 documented drug interactions.
Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.
benazepril (Lotensin) is a prescription ACE Inhibitor. Benazepril is used to treat high blood pressure (hypertension).
Benazepril (Lotensin) is a medicine that lowers your blood pressure. Lowering blood pressure helps to prevent strokes and heart attacks.
Verify with FDA → · CMS NADAC pricing →
Drug Pricing (NADAC)
Generic Price
$0.05/unit
Generic Available
Yes (6 manufacturers)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
Benazepril is used to treat high blood pressure (hypertension).
Common side effects
Headache, Dizziness, Feeling sleepy
Key warnings
If you become pregnant, stop taking benazepril right away and tell your doctor.
The sections below are summarized in plain English from benazepril's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
Benazepril is an ACE inhibitor. It works by relaxing your blood vessels. This makes it easier for your heart to pump blood.
Side Effects (from patient reports)
Based on 7,061 FDA adverse event reports.
Most-reported reactions
Adverse reactions in FAERS for benazepril, by number of reports
- Nausea
Nausea
439 reports
- Fatigue
Fatigue
408 reports
- Dizziness
Dizziness
382 reports
- Dyspnoea
Dyspnoea
381 reports
- Pain
Pain
361 reports
- Diarrhoea
Diarrhoea
356 reports
- Headache
Headache
344 reports
- Myocardial Infarction
Myocardial Infarction
310 reports
- Hypertension
Hypertension
295 reports
- Asthenia
Asthenia
269 reports
What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.
Reports over time
Adverse-event reports filed for benazepril each year to the FDA Adverse Event Reporting System (FAERS).
Year-to-year volume tracks usage, prescribing, and scrutiny, not a change in per-patient risk. Source: FDA FAERS.
Where benazepril sits
benazepril has more FDA adverse-event reports than 31% of the drugs FAERS tracks. A high position reflects how widely a drug is used and watched, not how dangerous it is.
Percentile across all drugs PlainMeds tracks by FAERS report volume. The dot is benazepril; the line is the median (50th percentile).
FDA Adverse Event Report Analysis
Detailed analysis of 7,061 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 1998–2025.
Total Reports
7,061
Reports Mentioning Death
572
8.1% of reports — not proof of cause
Hospitalization Reports
2,464
Top Indication
Hypertension
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 1 | NAUSEA | 439 |
| 2 | FATIGUE | 408 |
| 4 | DIZZINESS | 382 |
| 5 | DYSPNOEA | 381 |
| 6 | PAIN | 361 |
| 7 | DIARRHOEA | 356 |
| 8 | HEADACHE | 344 |
| 9 | MYOCARDIAL INFARCTION | 310 |
| 10 | HYPERTENSION | 295 |
| 11 | ASTHENIA | 269 |
| 12 | VOMITING | 257 |
| 13 | ANXIETY | 253 |
| 14 | CEREBROVASCULAR ACCIDENT | 248 |
| 15 | CARDIAC FAILURE CONGESTIVE | 240 |
| 16 | CHEST PAIN | 239 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
If you become pregnant, stop taking benazepril right away and tell your doctor. This medicine can harm or kill your unborn baby.
Known Drug Interactions
7.4 Dual Blockade of the Renin-Angiotensin System (RAS) Dual Blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. Do not coadminister aliskiren with benazepril hydrochloride in patients with diabetes. Avoid use of aliskiren with benazepril hydrochloride in patients with renal impairment (GFR < 60 ml/min).
Mechanism: These medicines both target the same pathway for blood pressure control, which increases the risk of kidney failure and high potassium. Using them together can cause your blood pressure to fall to unsafe levels.
Hyperkalemia Potassium-sparing diuretics (spironolactone, amiloride, triamterene, and others) can increase the risk of hyperkalemia.
Mechanism: Both of these medicines cause the body to hold onto potassium instead of getting rid of it through urine. This can lead to a dangerous buildup of potassium in your blood.
7 DRUG INTERACTIONS • Diuretics: Excessive drop in blood pressure ( 7.1 ) • Antidiabetics: Increased risk of hypoglycaemia ( 7.2 ) • NSAIDS: Increased risk of renal impairment and loss of antihypertensive efficacy ( 7.3 ) • Dual inhibition of the renin-angiotensin system: Increased risk of renal impairment, hypotension and hyperkalemia ( 7.4 ) • Lithium: Symptoms of lithium toxicity ( 7.6 ) • Neprilysin Inhibitor: Increased risk of angioedema ( Error! 7.6 Lithium Lithium toxicity has been reported in patients receiving lithium concomitantly with benazepril hydrochloride. Lithium toxicity...
Mechanism: Benazepril can make it harder for your kidneys to remove lithium from your body. This causes lithium to build up to levels that can be poisonous.
Hyperkalemia Potassium-sparing diuretics (spironolactone, amiloride, triamterene, and others) can increase the risk of hyperkalemia.
Mechanism: These two drugs both prevent the kidneys from flushing out potassium. Taking them together increases the risk that your potassium levels will become too high.
Benazepril Potassium Supplements and Potassium-Sparing Diuretics: Benazepril can attenuate potassium loss caused by thiazide diuretics. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors): In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including benazepril, may result in deterioration of renal function, including possible acute renal failure. Monitor renal function...
Mechanism: Taking both of these medications means you are taking the same medicine twice. This can lead to a higher risk of kidney problems or dangerously low blood pressure.
This is a plain-language summary of FDA-label interaction records and does not provide individual medication-combination directions.
Common Questions
Can I take benazepril if I am allergic to other ACE inhibitors?
Can I take benazepril if I have a history of angioedema?
Does benazepril interact with other medications?
How long does it take for benazepril to start working?
Can I drink alcohol while taking benazepril?
What should I do if I experience swelling while taking benazepril?
Can benazepril cause kidney problems?
Can benazepril cause high potassium?
Is it safe to take benazepril while breastfeeding?
Can benazepril cause a cough?
What are the common side effects of benazepril?
Does benazepril interact with other medications?
What drug class is benazepril?
What pregnancy or breastfeeding source fields are listed for benazepril?
Related Medications in ACE Inhibitor
Other drugs grouped near benazepril - same-class peers and common alternatives.
acebutolol
Sectral
Acebutolol is a medicine that helps lower blood pressure and control irregular heartbeats.
Compare with benazepril →
aliskiren
Tekturna
Tekturna is a medicine used to treat high blood pressure.
Compare with benazepril →
amiloride
Midamor
Amiloride is a water pill that helps your body hold onto potassium.
Compare with benazepril →
amlodipine
Norvasc
Amlodipine (Norvasc) is a drug that lowers blood pressure and treats chest pain.
Compare with benazepril →
amlodipine/benazepril
Lotrel
Lotrel is a combination medicine that contains amlodipine and benazepril.
Compare with benazepril →
Compare beyond drug class
Nationwide peers by FAERS volume & death-report share
Two PlainMeds-derived comparison paths for benazepril: nearest FDA FAERS report volume and nearest death-report share among drugs with at least 1,000 logged reports, excluding same-class neighbors listed above. Counts reflect reporting volume, not proven individual harm.
Similar FAERS report volume
Nearest drugs by total FAERS reports. This record: 7,061.
Similar death-report share
Nearest drugs by FAERS death-report share. This record: 8.10%.
- lovastatin Δ 0.00 pts · 25,229 reports · HMG-CoA Reductase Inhibitor (Statin) 8.11%death share
- escitalopram Δ 0.01 pts · 134,536 reports · Selective Serotonin Reuptake Inhibitor (SSRI) 8.11%death share
- gemfibrozil Δ 0.02 pts · 14,954 reports · Fibrate 8.08%death share
- nadolol Δ 0.04 pts · 7,398 reports · Non-Selective Beta-Blocker 8.14%death share
Medication Guides
Understanding Drug Interactions
How CYP450 enzymes, inhibitors, and inducers affect your medications
Generic vs Brand Name Drugs
FDA requirements, cost savings, and when the difference matters
Narrow Therapeutic Index Drugs
FDA bioequivalence and label-record context for narrow therapeutic index medicines
Common Drug Interactions
Dangerous medication combinations and how to protect yourself
Save on benazepril
Compare prices and find discounts at pharmacies near you. Free coupons can save up to 80% on prescriptions.
Disclosure: This link may earn us a commission at no extra cost to you. See our terms.
What the FDA Data Shows for benazepril
The FDA label for benazepril (sold under brand names such as Lotensin) classifies it as a prescription-only medication in the ACE Inhibitor class. Benazepril is used to treat high blood pressure (hypertension). Official labeling lists 4 commonly reported side effects, including Headache, Dizziness, Feeling sleepy.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 7,061 voluntary reports. The database also lists 5 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated major severity. NADAC pricing from CMS shows a generic unit cost of $0.05.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information are separate source-record fields. This page is a public FDA/CMS registry and does not provide medical, treatment, substitution, or medication-change directions.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. This registry does not provide medication decisions.
Last updated: January 12, 2026
PlainMeds is rendered directly from FDA openFDA/FAERS extracts, DailyMed labels, and CMS drug-pricing files, no number is typed in by an editor. FAERS counts, recalls, shortages, and price figures on this page are queried live from those federal extracts. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error. Data current as of 2026-05-15. Primary sources: openFDA / FAERS, DailyMed and CMS Part B ASP.
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled from the source snapshot dated . See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a data issue.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages