Benazepril and Aliskiren Interaction
Drug interaction information between Benazepril and Aliskiren.
Benazepril and Aliskiren have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Benazepril and Aliskiren. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medicines both target the same pathway for blood pressure control, which increases the risk of kidney failure and high potassium. Using them together can cause your blood pressure to fall to unsafe levels.
FDA Label Information
7.4 Dual Blockade of the Renin-Angiotensin System (RAS) Dual Blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. Do not coadminister aliskiren with benazepril hydrochloride in patients with diabetes. Avoid use of aliskiren with benazepril hydrochloride in patients with renal impairment (GFR < 60 ml/min).
Benazepril Also Interacts With
- Spironolactone moderate
- Lithium moderate
- Amiloride moderate
- Amlodipine/Benazepril minor
Aliskiren Also Interacts With
- Amlodipine/Benazepril major
- Amlodipine/Valsartan major
- Azilsartan major
- Candesartan major
- Enalapril major
Frequently Asked Questions
What SPL severity band is on file for Benazepril + Aliskiren?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aliskiren has 28 labeled pairs on file vs Benazepril's 5. In the major band specifically: Benazepril has 1; Aliskiren has 22 (also Amlodipine/Benazepril, Amlodipine/Valsartan, Azilsartan, Candesartan).
What mechanism field is on file for Benazepril and Aliskiren?
These medicines both target the same pathway for blood pressure control, which increases the risk of kidney failure and high potassium. Using them together can cause your blood pressure to fall to unsafe levels.
Aliskiren carries more major-labeled pairs than Benazepril
SPL source-record counts only. This page's band is major · classes on file: Benazepril (ACE Inhibitor); Aliskiren (Direct Renin Inhibitor).
Aliskiren has 22 major-labeled pairs vs Benazepril's 1.
1 major · 3 moderate · 1 minor · 5 total
Benazepril has no other major-band peer in this dataset besides Aliskiren.
22 major · 3 moderate · 3 minor · 28 total
- Other major peers for Aliskiren
- Amlodipine/Benazepril
- Amlodipine/Valsartan
- Azilsartan
- Candesartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.