Amlodipine/Benazepril and Spironolactone Interaction
Drug interaction information between Amlodipine/Benazepril and Spironolactone.
Amlodipine/Benazepril and Spironolactone have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Amlodipine/Benazepril and Spironolactone. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Both of these medications can cause your body to hold onto potassium instead of flushing it out. This can lead to dangerously high levels of potassium in your blood.
What To Do
Your doctor may need to check your blood potassium levels often or adjust your doses.
FDA Label Information
Potassium-sparing diuretics (spironolactone, amiloride, triamterene, and others) or potassium supplements can increase the risk of hyperkalemia. Potassium-sparing diuretics (spironolactone, amiloride, triamterene, and others) or potassium supplements can increase the risk of hyperkalemia.
Amlodipine/Benazepril Also Interacts With
- Amlodipine major
- Simvastatin major
- Lithium major
- Aliskiren major
- Amiloride moderate
Spironolactone Also Interacts With
- Lithium moderate
- Trimethoprim moderate
- Heparin moderate
- Benazepril moderate
- Lovastatin moderate
Frequently Asked Questions
Can I take Amlodipine/Benazepril and Spironolactone together?
This is a moderate interaction. Your doctor may need to check your blood potassium levels often or adjust your doses.
How serious is the interaction between Amlodipine/Benazepril and Spironolactone?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Amlodipine/Benazepril and Spironolactone interact?
Both of these medications can cause your body to hold onto potassium instead of flushing it out. This can lead to dangerously high levels of potassium in your blood.
Understanding the Amlodipine/Benazepril and Spironolactone Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Amlodipine/Benazepril belongs to the Calcium Channel Blocker / ACE Inhibitor Combination class and Spironolactone belongs to the Potassium-Sparing Diuretic / Aldosterone Antagonist class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Both of these medications can cause your body to hold onto potassium instead of flushing it out. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Amlodipine/Benazepril has 7 total documented interactions on file in this dataset, and Spironolactone has 23. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor may need to check your blood potassium levels often or adjust your doses. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Amlodipine/Benazepril or Spironolactone based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.