Aspirin and Duloxetine Interaction
Drug interaction information between Aspirin and Duloxetine.
Aspirin and Duloxetine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Aspirin and Duloxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medicines can make it harder for your blood to clot, which raises your risk of having a serious stomach bleed.
FDA Label Information
7.4 Drugs that Interfere with Hemostasis (e.g., NSAIDs, Aspirin, and Warfarin) Serotonin release by platelets plays an important role in hemostasis. Epidemiological studies of the case-control and cohort design that have demonstrated an association between use of psychotropic drugs that interfere with serotonin reuptake and the occurrence of upper gastrointestinal bleeding have also shown that concurrent use of an NSAID or aspirin may potentiate this risk of bleeding.
Aspirin Also Interacts With
- Atenolol major
- Fluoxetine major
- Ibandronate major
- Alendronate moderate
- Apixaban moderate
Duloxetine Also Interacts With
- Fluoxetine minor
- Famotidine minor
- Buspirone minor
- Paroxetine minor
- Lorazepam minor
Frequently Asked Questions
What SPL severity band is on file for Aspirin + Duloxetine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aspirin has 47 labeled pairs on file vs Duloxetine's 18. In the moderate band specifically: Aspirin has 12 (also Alendronate, Apixaban, Desvenlafaxine, Dexamethasone); Duloxetine has 1.
What mechanism field is on file for Aspirin and Duloxetine?
Both of these medicines can make it harder for your blood to clot, which raises your risk of having a serious stomach bleed.
Aspirin carries more major-labeled pairs than Duloxetine
SPL source-record counts only. This page's band is moderate · classes on file: Aspirin (Antiplatelet / NSAID); Duloxetine (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)).
Aspirin has 3 major-labeled pairs vs Duloxetine's 0. This page itself is in the moderate band, not the major band.
3 major · 12 moderate · 32 minor · 47 total
- Other moderate peers for Aspirin
- Alendronate
- Apixaban
- Desvenlafaxine
- Dexamethasone
0 major · 1 moderate · 17 minor · 18 total
Duloxetine has no other moderate-band peer in this dataset besides Aspirin.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.