Duloxetine and Buspirone Interaction
Drug interaction information between Duloxetine and Buspirone.
Duloxetine and Buspirone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Duloxetine and Buspirone. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Both of these medicines increase a brain chemical called serotonin, which can cause a dangerous reaction if levels get too high.
What To Do
Your doctor should watch you closely for symptoms like confusion, sweating, or a fast heart rate.
FDA Label Information
7.14 Other Serotonergic Drugs The concomitant use of serotonergic drugs (including other SNRIs, SSRIs, triptans, tricyclic antidepressants, opioids, lithium, buspirone, amphetamines, tryptophan, and St.
Duloxetine Also Interacts With
- Aspirin moderate
- Fluoxetine minor
- Famotidine minor
- Paroxetine minor
- Lorazepam minor
Buspirone Also Interacts With
- Tranylcypromine moderate
- Ziprasidone moderate
- Citalopram minor
- Darunavir minor
- Desvenlafaxine minor
Frequently Asked Questions
Can I take Duloxetine and Buspirone together?
This is a minor interaction. Your doctor should watch you closely for symptoms like confusion, sweating, or a fast heart rate.
How serious is the interaction between Duloxetine and Buspirone?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Duloxetine and Buspirone interact?
Both of these medicines increase a brain chemical called serotonin, which can cause a dangerous reaction if levels get too high.
Understanding the Duloxetine and Buspirone Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Duloxetine belongs to the Serotonin-Norepinephrine Reuptake Inhibitor (SNRI) class and Buspirone belongs to the Azapirone Anxiolytic class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Both of these medicines increase a brain chemical called serotonin, which can cause a dangerous reaction if levels get too high. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Duloxetine has 18 total documented interactions on file in this dataset, and Buspirone has 17. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should watch you closely for symptoms like confusion, sweating, or a fast heart rate. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Duloxetine or Buspirone based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.