Duloxetine and Buspirone Interaction
Drug interaction information between Duloxetine and Buspirone.
Duloxetine and Buspirone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Duloxetine and Buspirone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medicines increase a brain chemical called serotonin, which can cause a dangerous reaction if levels get too high.
FDA Label Information
7.14 Other Serotonergic Drugs The concomitant use of serotonergic drugs (including other SNRIs, SSRIs, triptans, tricyclic antidepressants, opioids, lithium, buspirone, amphetamines, tryptophan, and St.
Duloxetine Also Interacts With
- Aspirin moderate
- Fluoxetine minor
- Famotidine minor
- Paroxetine minor
- Lorazepam minor
Buspirone Also Interacts With
- Tranylcypromine moderate
- Ziprasidone moderate
- Citalopram minor
- Darunavir minor
- Desvenlafaxine minor
Frequently Asked Questions
What SPL severity band is on file for Duloxetine + Buspirone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Duloxetine has 18 labeled pairs on file vs Buspirone's 17. In the minor band specifically: Duloxetine has 17 (also Fluoxetine, Famotidine, Paroxetine, Lorazepam); Buspirone has 15 (also Citalopram, Darunavir, Desvenlafaxine, Diltiazem).
What mechanism field is on file for Duloxetine and Buspirone?
Both of these medicines increase a brain chemical called serotonin, which can cause a dangerous reaction if levels get too high.
Duloxetine's labeled portfolio outnumbers Buspirone
SPL source-record counts only. This page's band is minor · classes on file: Duloxetine (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)); Buspirone (Azapirone Anxiolytic).
0 major · 1 moderate · 17 minor · 18 total
- Other minor peers for Duloxetine
- Fluoxetine
- Famotidine
- Paroxetine
- Lorazepam
0 major · 2 moderate · 15 minor · 17 total
- Other minor peers for Buspirone
- Citalopram
- Darunavir
- Desvenlafaxine
- Diltiazem
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.