Aspirin and Dexamethasone Interaction
Drug interaction information between Aspirin and Dexamethasone.
Aspirin and Dexamethasone have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Aspirin and Dexamethasone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these drugs can irritate the lining of your stomach and digestive tract. Taking them together makes it more likely that you will develop stomach pain, ulcers, or bleeding.
FDA Label Information
Nonsteroidal Anti-Inflammatory Agents (NSAIDS): Concomitant use of aspirin (or other nonsteroidal ant i nflammatory agents) and corticosteroids increases the risk of gastrointestinal side effects. Aspirin should be used cautiously in conjunction with corticosteroids in hypoprothrombinemia.
Aspirin Also Interacts With
- Atenolol major
- Fluoxetine major
- Ibandronate major
- Alendronate moderate
- Apixaban moderate
Dexamethasone Also Interacts With
- Ketoconazole moderate
- Nirmatrelvir/Ritonavir moderate
- Warfarin minor
- Cyclosporine minor
- Hydrocortisone minor
Frequently Asked Questions
What SPL severity band is on file for Aspirin + Dexamethasone?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aspirin has 47 labeled pairs on file vs Dexamethasone's 21. In the moderate band specifically: Aspirin has 12 (also Alendronate, Apixaban, Desvenlafaxine, Duloxetine); Dexamethasone has 3 (also Ketoconazole, Nirmatrelvir/Ritonavir).
What mechanism field is on file for Aspirin and Dexamethasone?
Both of these drugs can irritate the lining of your stomach and digestive tract. Taking them together makes it more likely that you will develop stomach pain, ulcers, or bleeding.
Aspirin carries more major-labeled pairs than Dexamethasone
SPL source-record counts only. This page's band is moderate · classes on file: Aspirin (Antiplatelet / NSAID); Dexamethasone (Corticosteroid).
Aspirin has 3 major-labeled pairs vs Dexamethasone's 0. This page itself is in the moderate band, not the major band.
3 major · 12 moderate · 32 minor · 47 total
- Other moderate peers for Aspirin
- Alendronate
- Apixaban
- Desvenlafaxine
- Duloxetine
0 major · 3 moderate · 18 minor · 21 total
- Other moderate peers for Dexamethasone
- Ketoconazole
- Nirmatrelvir/Ritonavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.