What the FDA labels say about taking them together
Duloxetine and famotidine
Duloxetine's FDA label of May 14, 2024 names famotidine in its drug interactions section; the famotidine labels PlainMeds reads (2) do not name duloxetine.
Check it at the source: the duloxetine FDA label on DailyMed (effective May 14, 2024, SUN PHARMACEUTICAL INDUSTRIES, INC.); the famotidine FDA label on DailyMed (effective February 6, 2026, Kenvue Brands LLC).
What does the duloxetine label say about famotidine?
Duloxetine label, drug interactionsExamples; Aluminum-and magnesium-containing antacids, famotidine, proton pump inhibitors
Source: FDA drug label (DRIZALMA SPRINKLE), SUN PHARMACEUTICAL INDUSTRIES, INC., effective May 14, 2024 (SPL set b41423b8-dfec-4d79-ba3c-e43a87803d85), via openFDA; the full label on DailyMed
What does the famotidine label say about duloxetine?
Famotidine's label (effective February 6, 2026) and its 1 other brand-application label do not name duloxetine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Pepcid AC Original Strength), Kenvue Brands LLC, effective February 6, 2026 (SPL set 54f4086f-e443-4e7e-8c7e-94e152e1c256), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Duloxetine | Famotidine | |
|---|---|---|
| Labeled for | Depression, Anxiety, Nerve pain and fibromyalgia, Pain | Acid reflux and ulcers |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.102 per capsule 30 mg capsule | $0.0289 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once