Duloxetine and Lorazepam Interaction
Drug interaction information between Duloxetine and Lorazepam.
Duloxetine and Lorazepam have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Duloxetine and Lorazepam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two drugs do not have a significant effect on how the body handles or processes each other.
FDA Label Information
7.5 Lorazepam Under steady-state conditions for duloxetine (60 mg Q 12 hours) and lorazepam (2 mg Q 12 hours), the pharmacokinetics of duloxetine were not affected by co-administration.
Duloxetine Also Interacts With
- Aspirin moderate
- Fluoxetine minor
- Famotidine minor
- Buspirone minor
- Paroxetine minor
Lorazepam Also Interacts With
- Valproate minor
- Clozapine minor
- Probenecid minor
- Theophylline minor
- Aripiprazole minor
Frequently Asked Questions
What SPL severity band is on file for Duloxetine + Lorazepam?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Duloxetine has 18 labeled pairs on file vs Lorazepam's 11. In the minor band specifically: Duloxetine has 17 (also Fluoxetine, Famotidine, Buspirone, Paroxetine); Lorazepam has 11 (also Valproate, Clozapine, Probenecid, Theophylline).
What mechanism field is on file for Duloxetine and Lorazepam?
These two drugs do not have a significant effect on how the body handles or processes each other.
Duloxetine's labeled portfolio outnumbers Lorazepam
SPL source-record counts only. This page's band is minor · classes on file: Duloxetine (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)); Lorazepam (Benzodiazepine).
0 major · 1 moderate · 17 minor · 18 total
- Other minor peers for Duloxetine
- Fluoxetine
- Famotidine
- Buspirone
- Paroxetine
0 major · 0 moderate · 11 minor · 11 total
- Other minor peers for Lorazepam
- Valproate
- Clozapine
- Probenecid
- Theophylline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.