Duloxetine and Lorazepam Interaction
Drug interaction information between Duloxetine and Lorazepam.
Duloxetine and Lorazepam have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Duloxetine and Lorazepam. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
These two drugs do not have a significant effect on how the body handles or processes each other.
What To Do
No special dose adjustments are typically needed when taking these two medicines at the same time.
FDA Label Information
7.5 Lorazepam Under steady-state conditions for duloxetine (60 mg Q 12 hours) and lorazepam (2 mg Q 12 hours), the pharmacokinetics of duloxetine were not affected by co-administration.
Duloxetine Also Interacts With
- Aspirin moderate
- Fluoxetine minor
- Famotidine minor
- Buspirone minor
- Paroxetine minor
Lorazepam Also Interacts With
- Valproate minor
- Clozapine minor
- Probenecid minor
- Theophylline minor
- Aripiprazole minor
Frequently Asked Questions
Can I take Duloxetine and Lorazepam together?
This is a minor interaction. No special dose adjustments are typically needed when taking these two medicines at the same time.
How serious is the interaction between Duloxetine and Lorazepam?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Duloxetine and Lorazepam interact?
These two drugs do not have a significant effect on how the body handles or processes each other.
Understanding the Duloxetine and Lorazepam Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Duloxetine belongs to the Serotonin-Norepinephrine Reuptake Inhibitor (SNRI) class and Lorazepam belongs to the Benzodiazepine class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: These two drugs do not have a significant effect on how the body handles or processes each other. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Duloxetine has 18 total documented interactions on file in this dataset, and Lorazepam has 11. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: No special dose adjustments are typically needed when taking these two medicines at the same time. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Duloxetine or Lorazepam based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.