Desvenlafaxine and Warfarin Interaction
Drug interaction information between Desvenlafaxine and Warfarin.
Desvenlafaxine and Warfarin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Desvenlafaxine and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Desvenlafaxine is an antidepressant that can increase the risk of bleeding when combined with warfarin. It affects how your blood cells work together to stop bleeding.
Desvenlafaxine Also Interacts With
- Aspirin moderate
- Linezolid moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Selegiline moderate
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Desvenlafaxine + Warfarin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Desvenlafaxine's 19. In the moderate band specifically: Desvenlafaxine has 6 (also Aspirin, Linezolid, Phenelzine, Tranylcypromine); Warfarin has 28 (also Ibuprofen, Aspirin, Diclofenac, Vilazodone).
What mechanism field is on file for Desvenlafaxine and Warfarin?
Desvenlafaxine is an antidepressant that can increase the risk of bleeding when combined with warfarin. It affects how your blood cells work together to stop bleeding.
Warfarin carries more major-labeled pairs than Desvenlafaxine
SPL source-record counts only. This page's band is moderate · classes on file: Desvenlafaxine (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Warfarin has 2 major-labeled pairs vs Desvenlafaxine's 0. This page itself is in the moderate band, not the major band.
0 major · 6 moderate · 13 minor · 19 total
- Other moderate peers for Desvenlafaxine
- Aspirin
- Linezolid
- Phenelzine
- Tranylcypromine
2 major · 28 moderate · 133 minor · 163 total
- Other moderate peers for Warfarin
- Ibuprofen
- Aspirin
- Diclofenac
- Vilazodone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.