Ketoconazole and Abiraterone Interaction
Drug interaction information between Ketoconazole and Abiraterone.
Ketoconazole and Abiraterone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ketoconazole and Abiraterone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ketoconazole does not change how your body processes abiraterone. There is no significant interaction between these two drugs.
FDA Label Information
In a dedicated drug interaction trial, co-administration of ketoconazole, a strong inhibitor of CYP3A4, had no clinically meaningful effect on the pharmacokinetics of abiraterone [see Clinical Pharmacology ( 12.3 )].
Ketoconazole Also Interacts With
- Alfuzosin major
- Dronedarone major
- Ranolazine major
- Saxagliptin major
- Sildenafil major
Abiraterone Also Interacts With
- Thioridazine moderate
- Spironolactone (Acne) moderate
- Prednisone minor
- Pioglitazone minor
- Rifampin minor
Frequently Asked Questions
What SPL severity band is on file for Ketoconazole + Abiraterone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ketoconazole has 113 labeled pairs on file vs Abiraterone's 7. In the minor band specifically: Ketoconazole has 85 (also Acetaminophen/Oxycodone, Alosetron, Amphotericin B, Apixaban); Abiraterone has 5 (also Prednisone, Pioglitazone, Rifampin, Dextromethorphan).
What mechanism field is on file for Ketoconazole and Abiraterone?
Ketoconazole does not change how your body processes abiraterone. There is no significant interaction between these two drugs.
Ketoconazole carries more major-labeled pairs than Abiraterone
SPL source-record counts only. This page's band is minor · classes on file: Ketoconazole (Azole Antifungal); Abiraterone (CYP17 Inhibitor).
Ketoconazole has 6 major-labeled pairs vs Abiraterone's 0. This page itself is in the minor band, not the major band.
6 major · 22 moderate · 85 minor · 113 total
- Other minor peers for Ketoconazole
- Acetaminophen/Oxycodone
- Alosetron
- Amphotericin B
- Apixaban
0 major · 2 moderate · 5 minor · 7 total
- Other minor peers for Abiraterone
- Prednisone
- Pioglitazone
- Rifampin
- Dextromethorphan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.