Ketoconazole and Acetaminophen/Oxycodone Interaction
Drug interaction information between Ketoconazole and Acetaminophen/Oxycodone.
Ketoconazole and Acetaminophen/Oxycodone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ketoconazole and Acetaminophen/Oxycodone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ketoconazole slows down the process your body uses to break down the pain medicine, which can make the drug stay in your system longer and feel much stronger.
FDA Label Information
ketoconazole), and protease inhibitors (e.g., ritonavir), can increase the plasma concentration of oxycodone, resulting in increased or prolonged opioid effects.
Ketoconazole Also Interacts With
- Alfuzosin major
- Dronedarone major
- Ranolazine major
- Saxagliptin major
- Sildenafil major
Acetaminophen/Oxycodone Also Interacts With
- Gabapentin moderate
- Pregabalin moderate
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
Frequently Asked Questions
What SPL severity band is on file for Ketoconazole + Acetaminophen/Oxycodone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ketoconazole has 113 labeled pairs on file vs Acetaminophen/Oxycodone's 23. In the minor band specifically: Ketoconazole has 85 (also Abiraterone, Alosetron, Amphotericin B, Apixaban); Acetaminophen/Oxycodone has 21 (also Trazodone, Tramadol, Cyclobenzaprine, Oxycodone).
What mechanism field is on file for Ketoconazole and Acetaminophen/Oxycodone?
Ketoconazole slows down the process your body uses to break down the pain medicine, which can make the drug stay in your system longer and feel much stronger.
Ketoconazole carries more major-labeled pairs than Acetaminophen/Oxycodone
SPL source-record counts only. This page's band is minor · classes on file: Ketoconazole (Azole Antifungal); Acetaminophen/Oxycodone (Opioid Analgesic Combination).
Ketoconazole has 6 major-labeled pairs vs Acetaminophen/Oxycodone's 0. This page itself is in the minor band, not the major band.
6 major · 22 moderate · 85 minor · 113 total
- Other minor peers for Ketoconazole
- Abiraterone
- Alosetron
- Amphotericin B
- Apixaban
0 major · 2 moderate · 21 minor · 23 total
- Other minor peers for Acetaminophen/Oxycodone
- Trazodone
- Tramadol
- Cyclobenzaprine
- Oxycodone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.