Morphine and Verapamil Interaction
Drug interaction information between Morphine and Verapamil.
Morphine and Verapamil have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Morphine and Verapamil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Verapamil can change how your body processes and moves morphine. This may lead to higher levels of morphine in your blood than usual.
FDA Label Information
Examples: Quinidine, verapamil.
Morphine Also Interacts With
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
- Mirtazapine minor
- Linezolid minor
Verapamil Also Interacts With
- Eplerenone major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Clarithromycin moderate
Frequently Asked Questions
What SPL severity band is on file for Morphine + Verapamil?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Verapamil has 57 labeled pairs on file vs Morphine's 30. In the minor band specifically: Morphine has 30 (also Trazodone, Tramadol, Cyclobenzaprine, Mirtazapine); Verapamil has 47 (also Atorvastatin, Aspirin, Atenolol, Timolol).
What mechanism field is on file for Morphine and Verapamil?
Verapamil can change how your body processes and moves morphine. This may lead to higher levels of morphine in your blood than usual.
Verapamil carries more major-labeled pairs than Morphine
SPL source-record counts only. This page's band is minor · classes on file: Morphine (Opioid Analgesic); Verapamil (Calcium Channel Blocker).
Verapamil has 4 major-labeled pairs vs Morphine's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 30 minor · 30 total
- Other minor peers for Morphine
- Trazodone
- Tramadol
- Cyclobenzaprine
- Mirtazapine
4 major · 6 moderate · 47 minor · 57 total
- Other minor peers for Verapamil
- Atorvastatin
- Aspirin
- Atenolol
- Timolol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.