alprazolam vs digoxin
Side-by-side comparison of alprazolam and digoxin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
( 7.1 ) Use with Digoxin: Increase the risk of digoxin toxicity. Digoxin Clinical implication Increased digoxin concentrations have been reported when alprazolam was given, especially in geriatric patients (>65 years of age). Prevention or management In patients on digoxin therapy, measure serum digoxin concentrations before initiating alprazolam.
Recommendation: Your doctor should check your digoxin blood levels before you start taking alprazolam.
Xanax
Lanoxin
Alprazolam (Xanax) is a medication that can help you with anxiety and panic disorders. It belongs to a class of drugs called benzodiazepines, which work by slowing down activity in the brain.
Digoxin (Lanoxin) is a medicine that helps your heart pump better. It is used to treat heart failure and control irregular heartbeats.
Alprazolam is used to treat generalized anxiety disorder (GAD) and panic disorder (PD) in adults. GAD involves excessive worry and tension, while PD causes sudden and intense episodes of fear. This medicine can help reduce these symptoms.
Digoxin is used to treat mild to moderate heart failure in adults. It helps the heart pump more blood with each beat. Digoxin is also used in children with heart failure to help their heart work better. In adults, it can control a fast and irregular heartbeat called atrial fibrillation.
Alprazolam works by affecting certain chemicals in your brain called neurotransmitters. It enhances the effects of a neurotransmitter called GABA, which helps to calm your nerves. This can reduce feelings of anxiety and panic.
Digoxin belongs to a class of drugs called cardiac glycosides. It works by making the heart muscle contract more strongly. It also slows down the electrical signals in the heart, which can help control irregular heartbeats.
- • Drowsiness
- • Light-headedness
- • Dry mouth
- • Nausea
- • Vomiting
- • Diarrhea
- • Dizziness
- • Headache
- Feeling sick to your stomach 12,854
- Feeling tired 11,935
- Misusing the drug 10,943
- Feeling worried or nervous 10,169
- Pain in your head 9,923
- Shortness of breath 6,062
- Feeling sick to your stomach 4,747
- Feeling lightheaded or unsteady 4,442
- Feeling very tired 4,174
- Irregular heartbeat 3,972
Alprazolam can be habit-forming, leading to abuse, misuse, and addiction, which can result in overdose or death. Taking alprazolam with opioid pain medicines can cause severe sleepiness, breathing problems, coma, and death. Suddenly stopping alprazolam can cause life-threatening withdrawal symptoms. Talk to your doctor about how to safely stop taking it.
Digoxin can cause serious side effects, including dangerous heart rhythms. You are at higher risk if you have certain heart conditions or kidney problems. Tell your doctor right away if you have nausea, vomiting, vision changes, or an irregular heartbeat.
Taking alprazolam late in pregnancy can cause sedation or withdrawal symptoms in the newborn. Breastfeeding is not recommended while taking alprazolam because it can cause sedation and feeding problems in the baby.
It is not known if digoxin can harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. The medicine passes into breast milk, but it is unlikely to harm the baby.
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How to Read This alprazolam vs digoxin Comparison
alprazolam is classified in the Benzodiazepine drug class, while digoxin sits within the Cardiac Glycoside class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, alprazolam has 55,824 submissions while digoxin has 23,397. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to alprazolam can cause digoxin levels to build up in the body, which can lead to dangerous side effects. this happens more often in patients over the age of 65.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between alprazolam and digoxin - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.