What the FDA labels say about taking them together
Ivabradine and verapamil
Ivabradine's FDA label of November 10, 2025 names verapamil in its drug interactions section, and verapamil's label names ivabradine too. The verapamil label: “Ivabradine Concurrent use of verapamil increases exposure to ivabradine and may exacerbate bradycardia and conduction disturbances.”
Check it at the source: the ivabradine FDA label on DailyMed (effective November 10, 2025); the verapamil FDA label on DailyMed (effective April 6, 2026, Zydus Pharmaceuticals (USA) Inc.).
What does the ivabradine label say about verapamil?
Ivabradine label, drug interactionsAvoid concomitant use of moderate CYP3A4 inhibitors when using Corlanor. Examples of moderate CYP3A4 inhibitors include diltiazem, verapamil, and grapefruit juice [ s ee Warnings and Precautions ( 5.3 ) and Clinical Pharmacology ( 12.3 )].
Ivabradine label, warnings and precautionsRisk factors for bradycardia include sinus node dysfunction, conduction defects (e.g., 1 st or 2 nd degree atrioventricular block, bundle branch block), ventricular dyssynchrony, and use of other negative chronotropes (e.g., digoxin, diltiazem, verapamil, amiodarone).
Source: FDA drug label (Corlanor), Amgen Inc, effective November 10, 2025 (SPL set 92018a65-38f6-45f7-91d4-a34921b81d0d), via openFDA; the full label on DailyMed
What does the verapamil label say about ivabradine?
Verapamil label, drug interactionsConcurrent use of verapamil increases exposure to ivabradine and may exacerbate bradycardia and conduction disturbances. Avoid co-administration of verapamil and ivabradine.
Source: FDA drug label (Verapamil Hydrochloride, NDA019614), Wilshire Pharmaceuticals, Inc., effective November 27, 2024 (SPL set f9399858-fd7a-4b73-8759-3e5bf3af2666), via openFDA
Source: FDA drug label (Verapamil hydrochloride), Zydus Pharmaceuticals (USA) Inc., effective April 6, 2026 (SPL set e19ab8d8-dae5-489d-9805-7e7407bea06d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ivabradine | Verapamil | |
|---|---|---|
| Labeled for | Heart failure | High blood pressure, Atrial fibrillation, Angina |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.761 per tablet 5 mg tablet | $0.191 per tablet 180 mg tablet |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once