What the FDA labels say about taking them together
Diltiazem and ivabradine
Diltiazem's FDA label of August 7, 2026 names ivabradine in its drug interactions section, and ivabradine's label names diltiazem too. The diltiazem label: “Concurrent use of diltiazem increases exposure to ivabradine and may exacerbate bradycardia and conduction disturbances.”
Check it at the source: the diltiazem FDA label on DailyMed (effective August 7, 2026, Bausch Health US, LLC); the ivabradine FDA label on DailyMed (effective November 10, 2025).
What does the diltiazem label say about ivabradine?
Diltiazem label, drug interactionsConcurrent use of diltiazem increases exposure to ivabradine and may exacerbate bradycardia and conduction disturbances.
Source: FDA drug label (TIAZAC EXTENDED RELEASE), Bausch Health US, LLC, effective August 7, 2026 (SPL set c567fe7e-887e-4291-a0d1-2dd3f25cbf25), via openFDA; the full label on DailyMed
What does the ivabradine label say about diltiazem?
Ivabradine label, drug interactionsAvoid concomitant use of moderate CYP3A4 inhibitors when using Corlanor. Examples of moderate CYP3A4 inhibitors include diltiazem, verapamil, and grapefruit juice [ s ee Warnings and Precautions ( 5.3 ) and Clinical Pharmacology ( 12.3 )].
Ivabradine label, warnings and precautionsRisk factors for bradycardia include sinus node dysfunction, conduction defects (e.g., 1 st or 2 nd degree atrioventricular block, bundle branch block), ventricular dyssynchrony, and use of other negative chronotropes (e.g., digoxin, diltiazem, verapamil, amiodarone).
Source: FDA drug label (Corlanor), Amgen Inc, effective November 10, 2025 (SPL set 92018a65-38f6-45f7-91d4-a34921b81d0d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Diltiazem | Ivabradine | |
|---|---|---|
| Labeled for | High blood pressure, Angina, Atrial fibrillation | Heart failure |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.144 per capsule 24h ER(cd) 120 mg capsule | $0.761 per tablet 5 mg tablet |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once