Diltiazem and Ivabradine Interaction
Drug interaction information between Diltiazem and Ivabradine.
Diltiazem and Ivabradine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Diltiazem and Ivabradine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Diltiazem increases the amount of ivabradine in your body, which can slow your heart rate down to a dangerous level.
FDA Label Information
Ivabradine : Concurrent use of diltiazem increases exposure to ivabradine and may exacerbate bradycardia and conduction disturbances. Avoid concomitant use of ivabradine and diltiazem.
Diltiazem Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Theophylline major
- Rifampin moderate
Ivabradine Also Interacts With
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Voriconazole major
- Digoxin moderate
Frequently Asked Questions
What SPL severity band is on file for Diltiazem + Ivabradine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Diltiazem has 46 labeled pairs on file vs Ivabradine's 10. In the moderate band specifically: Diltiazem has 7 (also Rifampin, Digoxin, Aprepitant, Metoprolol); Ivabradine has 2 (also Digoxin).
What mechanism field is on file for Diltiazem and Ivabradine?
Diltiazem increases the amount of ivabradine in your body, which can slow your heart rate down to a dangerous level.
Diltiazem's labeled portfolio outnumbers Ivabradine
SPL source-record counts only. This page's band is moderate · classes on file: Diltiazem (Calcium Channel Blocker); Ivabradine (HCN Channel Blocker).
4 major · 7 moderate · 35 minor · 46 total
- Other moderate peers for Diltiazem
- Rifampin
- Digoxin
- Aprepitant
- Metoprolol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.