Prescription medicine
Calcium chloride
Calcium chloride is a prescription medicine with an FDA approval on record since 2000. FDA's NDC Directory lists it from 13 generic labelers.
- Generic listed
- A presentation discontinued
Check it at the source: the calcium chloride FDA label on DailyMed (effective February 2, 2026, Hospira, Inc.); the NDA 21117 record on Drugs@FDA; every calcium chloride label on DailyMed.
Highlights of the record
FDA label of February 2, 2026; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026
Used for
From the label: indications and usageCalcium Chloride Injection is indicated for the treatment of adult and pediatric patients with acute symptomatic hypocalcemia.
Forms and strengths
- 100 mg/ml
Injection (solution); injection.
On the market
- Earliest approval on file
- January 28, 2000 Calcium Chloride 10% In Plastic Container, Hospira; Drugs@FDA’s file, where older or withdrawn approvals can be missing
- Generic approvals
- 7 first July 27, 2017; 7 with a marketed status in Drugs@FDA
- Labelers listed (NDC)
- 15 of which 13 under generic applications, 4 under brand applications, repackagers included
Supply and safety
- Pharmacy cost (NADAC)
- Not in the survey
- Shortage (FDA)
- None current 1 past records
- Recalls by its makers (FDA)
- 3 since 2012 0 Class I among all firms' recalls; latest July 30, 2025; 9 more by firms not listed as its makers
- FAERS reports
- 3,072 through July 30, 2026
What is calcium chloride used for?
From the label: indications and usageCalcium Chloride Injection is indicated for the treatment of adult and pediatric patients with acute symptomatic hypocalcemia. Limitations of Use The safety and effectiveness of Calcium Chloride Injection for long-term use has not been established. Calcium Chloride Injection is a form of calcium indicated for the treatment of adult and pediatric and patients with acute symptomatic hypocalcemia. ( 1 ) Limitations of Use: The safety and effectiveness of Calcium Chloride Injection for long-term use has not been established.
FDA pharmacologic class: Blood Coagulation Factor and Phosphate Binder.
Source: FDA drug label (Calcium Chloride), Hospira, Inc., effective February 2, 2026 (SPL set c4c65e48-85f8-4dcf-6281-06e40959cc79), via openFDA; the full label on DailyMed
Is there a generic for calcium chloride?
The FDA approved the first generic calcium chloride on July 27, 2017. 7 generic applications are approved; 7 of them carry a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale.
FDA's NDC Directory lists calcium chloride from 13 labelers under a generic (ANDA) application and from 4 brand labelers. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.
- 2000 earliest approval on file
- 2017 first generic approved
- red ticks recalls
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
Is calcium chloride in shortage?
No calcium chloride presentation is listed as in shortage in the FDA Drug Shortage Database (read October 8, 2026); its 1 record is all marked to be discontinued, the latest updated November 7, 2025. ASHP keeps a separate shortage list, which can differ.
| Presentation | Company | Status | Updated |
|---|---|---|---|
| Calcium Chloride, Injection, 100 mg/1 mL (NDC 0409-4928-34) | Hospira, Inc., a Pfizer Company | To Be Discontinued | November 7, 2025 |
Every calcium chloride presentation in the FDA shortage database
Source: FDA Drug Shortage Database via openFDA, updated October 8, 2026
Has calcium chloride been recalled?
The FDA's Enforcement Report lists 12 recalls naming calcium chloride since 2012: 0 Class I (the most serious), 12 Class II, 0 Class III; 1 still ongoing. 9 of them are by firms that FDA's NDC Directory does not list as a maker of calcium chloride and that hold no application for it in Drugs@FDA, such as compounding pharmacies or bulk-ingredient suppliers; the recall notice names the product recalled. A recall names products and lots, not every product of the medicine.
| Started | Class | Company | Reason |
|---|---|---|---|
| July 30, 2025 | Class II | GenoGenix LLC | Lack of Assurance of Sterility |
| August 13, 2021 | Class II | First Royal Care Co. LLC, dba Red Mountain Compounding … not a listed maker | Lack of Assurance of Sterility: FDA inspection raised sterility assurance concerns |
| January 15, 2020 | Class II | Fusion IV Pharmaceuticals, Inc. dba Axia Pharmaceutical not a listed maker | Lack of Assurance of Sterility |
| June 19, 2019 | Class II | RXQ Compounding LLC not a listed maker | Lack of Assurance of Sterility |
| November 18, 2016 | Class II | Cantrell Drug Company | Lack of Assurance of Sterility - the firm is recalling select sterile drug products. |
| October 19, 2015 | Class II | Western Drug not a listed maker | Lack of Assurance of Sterility |
| October 6, 2014 | Class II | Oregon Compounding Centers, Inc. dba Creative Compounds not a listed maker | Lack of Sterility Assurance: All lots of sterile products compounded by the pharmacy that are not expired due to concerns associated with quality control … |
| August 27, 2014 | Class II | Martin Avenue Pharmacy, Inc. not a listed maker | Lack of Assurance of Sterility: Martin Avenue Pharmacy, Inc. is conducting a voluntary recall of all compounded sterile preparations within expiry. … |
Source: FDA Enforcement Report (drug recalls) via openFDA, through October 8, 2026
What does the calcium chloride label say about other medicines?
The calcium chloride label names 6 other medicines in its interaction, contraindication or warning sections. The labels of 2 other medicines name calcium chloride. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.
| Medicine named | Section | What the label says |
|---|---|---|
| Calcipotriene | drug interactions | Increase the Risk of Hypercalcemia Increase frequency of monitoring of calcium concentrations in patients taking concomitant Calcium Chloride Injection and other drugs that increase the risk of hypercalcemia (e.g., calcipotriene, estrogen, lithium, parathyroid hormone, teriparatide, thiazide diuretics, Vitamin A, and … |
| Ceftriaxone | contraindications | Patients with asystole and electromechanical dissociation Newborns (up to 28 days of age) if they require (or are expected to require) ceftriaxone intravenous treatment because of the risk of precipitation of ceftriaxone-calcium, regardless of whether these products would be received at different times or through … |
| Digoxin | drug interactions | Avoid the concomitant use of Calcium Chloride Injection with digoxin. |
| Lithium | drug interactions | Increase the Risk of Hypercalcemia Increase frequency of monitoring of calcium concentrations in patients taking concomitant Calcium Chloride Injection and other drugs that increase the risk of hypercalcemia (e.g., calcipotriene, estrogen, lithium, parathyroid hormone, teriparatide, thiazide diuretics, Vitamin A, and … |
| Teriparatide | drug interactions | … drugs that increase the risk of hypercalcemia (e.g., calcipotriene, estrogen, lithium, parathyroid hormone, teriparatide, thiazide diuretics, Vitamin A, and Vitamin D). |
| Vitamin a | drug interactions | … hypercalcemia (e.g., calcipotriene, estrogen, lithium, parathyroid hormone, teriparatide, thiazide diuretics, Vitamin A, and Vitamin D). |
Other labels that name calcium chloride
Source: FDA drug label (Calcium Chloride), Hospira, Inc., effective February 2, 2026 (SPL set c4c65e48-85f8-4dcf-6281-06e40959cc79), via openFDA; the full label on DailyMed
What do FAERS reports show for calcium chloride?
The FDA Adverse Event Reporting System holds 3,072 reports that list calcium chloride among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 720 are coded as a death and 1,387 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Reports received each year
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What next?
- Other blood coagulation factors
- the pharmacologic class, with prices and generics
- Calcium chloride side effects
- the label's list beside FAERS reports
- Calcium chloride shortage record
- every presentation, company and date
- Check an interaction
- what two or more labels say about each other